E1/E2/E3 Enzyme
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Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E1-E2-E3 cascade onto target proteins. The E1 enzyme is the activating enzyme, to which ubiquitin is attached in an ATP-dependent reaction by a thioester bond. The E2 enzyme is the conjugating enzyme, to which the ubiquitin is transferred from the E1. The E3 is the ubiquitin ligase, which directly or indirectly catalyzes the transfer of the ubiquitin to the target protein (the substrate), with the formation of an isopeptide bond.
Products Related to E1/E2/E3 Enzyme(125)
- GC73155Rugonersen sodiumCAS: 2591588-58-6Purity: >91.00%
Rugonersen sodiumは、ロック核酸(lna)修飾されたアンチセンスオリゴヌクレオチド(aso)であり、ユビキチン-タンパク質リガーゼe3a (ube3a)のサイレンシングを減少させる。
- GC73229Smurf1-IN-1CAS: 1824708-03-3Purity: >99.00%
Smurf1-IN-1は、ic50が92 nmの特異的e3ユビキチンプロテインリガーゼ1 (smurf1)の経口活性および選択的阻害剤である。
- GC73363Antitumor agent-81CAS: 2765180-17-2Purity: >98.00%
Antitumor agent-81(化合物5a)は細胞毒性の低いp62-rnf168アゴニストであり、p62とrnf168の相互作用を増強する。
- GC73512Skp2 inhibitor 2CAS: 2760612-77-7
Skp2 inhibitor 2（14 f）はF-boxタンパク質S期キナーゼ関連タンパク質2（Skp 2）の阻害剤であり、IC 50値は10.2μM（Skp 2-Cks 1）である。
- GC79629ZER1 binder-2CAS: 3132618-63-1Purity: >98.00%
ZER1 binder-2 is a ZER1 E3 ubiquitin ligase binder with an EC 50 value of 51.04 nM.
- GC79631JWP24 acetatePurity: >98.00%
JWP24 acetate is the first cell membrane-permeable peptide inhibitor of MAGE-A4, with an IC 50 of 200 nM against human MAGE-A4.
- GC79727Tracer AL244Purity: >98.50%
Tracer AL244 is a BODIPY-based fluorescent tracer and also a TRIM21 binder.
- GC80879JWZ-8-103 hydrochloridePurity: >99.50%
JWZ-8-103 hydrochloride is an orally active analog of PRLX-93936 and a molecular glue targeting TRIM21.
- GC81024PROTAC RNF4 degrader-1Purity: >98.00%
PROTAC RNF4 degrader-1 is a RNF4 PROTAC degrader ( K d = 64.5 nM) that degrades RNF4 via the ubiquitin-proteasome system.
- GC81026PROTAC SKP2 Degrader-1CAS: 3120650-15-6Purity: >99.50%
PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC71320 | Cbl-b-IN-5 | 2368835-59-8 | >99.00% | |
Cbl-b-IN-5（化合物6）はCbl−b阻害剤（IC 50=3-10µM）である。 | ||||
| GC73155 | Rugonersen sodium | 2591588-58-6 | >91.00% | |
Rugonersen sodiumは、ロック核酸(lna)修飾されたアンチセンスオリゴヌクレオチド(aso)であり、ユビキチン-タンパク質リガーゼe3a (ube3a)のサイレンシングを減少させる。 | ||||
| GC73229 | Smurf1-IN-1 | 1824708-03-3 | >99.00% | |
Smurf1-IN-1は、ic50が92 nmの特異的e3ユビキチンプロテインリガーゼ1 (smurf1)の経口活性および選択的阻害剤である。 | ||||
| GC73363 | Antitumor agent-81 | 2765180-17-2 | >98.00% | |
Antitumor agent-81(化合物5a)は細胞毒性の低いp62-rnf168アゴニストであり、p62とrnf168の相互作用を増強する。 | ||||
| GC73485 | UC-764864 | 278806-03-4 | >99.00% | |
UC-764864はUBE 2 N阻害剤である。 | ||||
| GC73512 | Skp2 inhibitor 2 | 2760612-77-7 | - | |
Skp2 inhibitor 2（14 f）はF-boxタンパク質S期キナーゼ関連タンパク質2（Skp 2）の阻害剤であり、IC 50値は10.2μM（Skp 2-Cks 1）である。 | ||||
| GC73748 | PELI1-IN-1 | - | >98.00% | |
PELI1-IN-1 (compound 3d)はpeli1, e3ユビキチンリガーゼの強力な阻害剤である。 | ||||
| GC73800 | MS181 | - | >98.00% | |
MS181 (compound 1)は、強力なセレブロン(crbn)リクルートおよびeed-binding polycomb repressive complex 1 (prc1) protac分解体である。 | ||||
| GC73900 | HA-9104 | 2412367-83-8 | >98.00% | |
HA-9104は、UBE 2 FのV 30ポケットにほぼターゲットを当てることでcullin-5 nedylationを抑制する有効な選択的抑制剤である。 | ||||
| GC74157 | EN450 | 793719-01-4 | >99.00% | |
EN450はNF−κBに対するシステイン反応性共有結合分子ゲル分解剤である。 | ||||
| GC79075 | NVS1.1 | - | >98.00% | |
NVS1.1 is an orally active, blood-brain barrier-penetrant eRF1 degrader. | ||||
| GC79626 | H111-H7 | 220965-54-8 | >98.00% | |
H111-H7 is a WW domain containing E3 ubiquitin 27 protein ligase 2 ( WWP2 ) inhibitor with a K D of 717 nM. | ||||
| GC79627 | H36-E4 | 688310-17-0 | >98.50% | |
H36-E4 is a WW domain containing E3 ubiquitin 27 protein ligase 2 ( WWP2 ) inhibitor with a K D of 6.25 μM. | ||||
| GC79628 | XMU-MP-10 | 2251132-02-0 | >98.00% | |
XMU-MP-10 is a selective NEDD4 inhibitor with a K D of 43.92 nM. | ||||
| GC79629 | ZER1 binder-2 | 3132618-63-1 | >98.00% | |
ZER1 binder-2 is a ZER1 E3 ubiquitin ligase binder with an EC 50 value of 51.04 nM. | ||||
| GC79630 | MRC37 | - | >98.50% | |
MRC37 is a high-affinity TRIM21 ligand with a K d of 0.4 µM. | ||||
| GC79631 | JWP24 acetate | - | >98.00% | |
JWP24 acetate is the first cell membrane-permeable peptide inhibitor of MAGE-A4, with an IC 50 of 200 nM against human MAGE-A4. | ||||
| GC79725 | DI-1548 | 2247060-97-3 | >98.00% | |
DI-1548 is a potent, selective, and irreversible covalent inhibitor of DCN1 ( IC 50 = 4.6 nM). | ||||
| GC79727 | Tracer AL244 | - | >98.50% | |
Tracer AL244 is a BODIPY-based fluorescent tracer and also a TRIM21 binder. | ||||
| GC80879 | JWZ-8-103 hydrochloride | - | >99.50% | |
JWZ-8-103 hydrochloride is an orally active analog of PRLX-93936 and a molecular glue targeting TRIM21. | ||||
| GC80921 | CCT400028 | - | >98.00% | |
CCT400028 is a PROTACs -class degrader that targets the Aurora A (AURKA) kinase. | ||||
| GC81022 | JWZ-8-103 | 3110272-60-8 | >98.00% | |
JWZ-8-103 is an orally active analog of PRLX-93936 and a molecular glue targeting TRIM21. | ||||
| GC81024 | PROTAC RNF4 degrader-1 | - | >98.00% | |
PROTAC RNF4 degrader-1 is a RNF4 PROTAC degrader ( K d = 64.5 nM) that degrades RNF4 via the ubiquitin-proteasome system. | ||||
| GC81026 | PROTAC SKP2 Degrader-1 | 3120650-15-6 | >99.50% | |
PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM. | ||||