Ribociclib D6 (Synonyms: LEE011-d6) |
| カタログ番号GC60324 |
リボシクリブ D6 (LEE011 D6) は、リボシクリブと標識された重水素です。 Ribociclib は、それぞれ 10 nM および 39 nM の IC50 値を持つ非常に特異的な CDK4/6 阻害剤であり、サイクリン B/CDK1 複合体に対しては 1,000 倍以上強力ではありません。
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Cas No.: 1328934-40-2
Sample solution is provided at 25 µL, 10mM.
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Ribociclib D6 (LEE011 D6) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].
[1]. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.
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