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KAS 08

Catalog No.GC52291

A STING activator

Products are for research use only. Not for human use. We do not sell to patients.

KAS 08 Chemical Structure

Cas No.: 203861-20-5

Size Price Stock Qty
1 mg
$147.00
In stock
5 mg
$659.00
In stock
10 mg
$1,245.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

KAS 08 is an activator of stimulator of interferon genes (STING).1 It activates STING with an EC50 value of 0.33 µM in a reporter assay using THP-1 human monocytes. KAS 08 increases the levels of IFN-β and IP-10 in the presence, but not absence, of cGAMP. It reduces the viability of CT26 mouse colorectal cancer cells when used at concentrations ranging from 0.31 to 20 µM. KAS 08 (15 mg/kg), when administered in combination with exogenous 2'3'-cGAMP , reduces tumor growth in a CT26 mouse syngeneic model.

1.Jung, H.R., Jo, S., Jeon, M.J., et al.Development of small-molecule STING activators for cancer immunotherapyBiomedicines10(1)33(2022)

Chemical Properties

Cas No. 203861-20-5 SDF Download SDF
Canonical SMILES O=C(C1=CC=C([N+]([O-])=O)C=C1)N2CCC3=CC(S(=O)(N4C(N[C@](C5=CC=CC=C5)([H])C4)=O)=O)=CC=C32
Formula C24H20N4O6S M.Wt 492.5
Solubility DMF: 16 mg/mL,DMSO: 12 mg/mL,Ethanol: 12 mg/mL,PBS (pH 7.2): 0.25 mg/mL Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.0305 mL 10.1523 mL 20.3046 mL
5 mM 0.4061 mL 2.0305 mL 4.0609 mL
10 mM 0.203 mL 1.0152 mL 2.0305 mL
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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