>>Signaling Pathways>> Stem Cell>> Wnt/β-catenin>>ABC99

ABC99

Catalog No.GC42669

ABC99는 Wnt 탈아실화 효소 NOTUM(IC50=13nM)을 선택적으로 억제하는 N-하이드록시히단토인(NHH) 카바메이트입니다. ABC99는 NOTUM이 있는 경우 Wnt3A 신호를 유지합니다.

Products are for research use only. Not for human use. We do not sell to patients.

ABC99 Chemical Structure

Cas No.: 2331255-53-7

Size 가격 재고 수량
500ug
US$114.00
재고 있음
1mg
US$215.00
재고 있음
5mg
US$782.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 3 publications

Description Chemical Properties Product Documents Related Products

ABC99 is an N-hydroxyhydantoin (NHH) carbamate that inhibits the Wnt-deacylating enzyme NOTUM (IC50 = 13 nM).[1] It preserves Wnt3A signaling in the presence of NOTUM (EC50 = 89 nM in a cell-based reporter assay).

Reference:
[1]. Suciu, R.M., Cognetta, A.B., III., Potter, Z.E., et al. Selective irreversible inhibitors of the Wnt-deacylating enzyme NOTUM developed by activity-based protein profiling. ACS Med. Chem. Lett. 9(6), 563-568 (2018).

리뷰

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Average Rating: 5 ★★★★★ (Based on Reviews and 37 reference(s) in Google Scholar.)

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