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Acetyl-CoA Carboxylase

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Acetyl-CoA carboxylase (ACC) is a biotin carboxylase that catalyzes the ATP-dependent condensation of acetyl-CoA and carbonate to form malonyl-CoA. The malonyl-CoA produced by ACC serves two major physiologic functions. It is an essential and rate-limiting substrate for de novo lipogenesis (DNL), and it acts as an allosteric inhibitor of the enzyme carnitine-palmitoyl transferase I (CPT-1). Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential for the treatment of type 2 diabetes mellitus (T2DM), hepatic steatosis, and cancer.

Acetyl-CoA carboxylase (ACC) in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks CPT-1 function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).

Products Related to Acetyl-CoA Carboxylase(21)

  • GC27869 structure
    GC27869hACC2-IN-1
    CAS: 192323-14-1
    Purity: >99.50%

    hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC 50 value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research.

  • GC27870 structure
    GC27870ACC1/2-IN-2
    CAS: 1031411-94-5
    Purity: >99.00%

    ACC1/2-IN-2 (compound PF-3) is a potent ACC1/2 inhibitor with IC 50 values of 22 and 48 nM for ACC1 and ACC2, respectively.

  • GC13434 structure
    GC13434CP-640186
    CAS: 591778-68-6
    Purity: >98.50%

    CP-640186은 쥐 간 ACC1 및 쥐 골격근 ACC2에 대해 각각 53nM 및 61nM의 IC50을 갖는 경구 활성 및 세포 투과성 아세틸-CoA 카르복실라제(ACC) 억제제입니다.

  • GC19261 structure
    GC19261ND-630 (Firsocostat)
    CAS: 1434635-54-7
    Purity: >98.00%

    ND-630 (Firsocostat)는 아세틸-CoA 카르복실라제(ACC) 억제제로 ACC1(IC₅₀=2.1 nM)과 ACC2(IC₅₀=6.1 nM)의 활성을 억제한다.

  • GC19284 structure
    GC19284PF-05175157
    CAS: 1301214-47-0
    Purity: >98.00%

    PF-05175157은 ACC1(인간), ACC2(인간), ACC1(쥐), ACC2(쥐)에 대해 IC50이 각각 27.0, 33.0, 23.5 및 50.4nM인 넓은 스펙트럼의 아세틸-CoA 카르복실라제(ACC) 억제제입니다.

  • GC25726 structure
    GC25726PF-05221304
    CAS: 1370448-25-1
    Purity: >98%

    PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL).

  • GC30047 structure
    GC30047Olumacostat glasaretil
    CAS: 1261491-89-7
    Purity: >98.50%

    올루마코스타트 글라사레틸은 아세틸 조효소 A 카르복실라제(ACC)의 소분자 억제제입니다.

  • GC31344 structure
    GC31344MK-4074
    CAS: 1039758-22-9
    Purity: >99.50%

    MK-4074는 IC50 값이 약 3nM인 아세틸-CoA 카르복실라제 ACC1 및 ACC2의 간 특이적 억제제입니다.

  • GC32706 structure
    GC32706ND-646
    CAS: 1434639-57-2
    Purity: >98.50%

    ND-646는 구조적으로 이용 가능한 경구용 아세틸-CoA 카복실라아제(ACC) 억제제로, 재조합 hACC1 및 hACC2에 대한 IC50가 각각 3.5nM 및 4.1nM입니다.

  • GC32715 structure
    GC32715TOFA (RMI14514)
    CAS: 54857-86-2
    Purity: >98.00%

    TOFA (RMI14514)는 acetyl-CoA 첨화효소-α (ACCA)의 구상 억제제이다.

  • GC35740 structure
    GC35740CP-640186 hydrochloride
    CAS: 591778-70-0
    Purity: >99.50%

    CP-640186 염산염은 쥐 간 ACC1 및 쥐 골격근 ACC2에 대해 각각 53nM 및 61nM의 IC50을 갖는 경구 활성 및 세포 투과성 아세틸-CoA 카르복실라제(ACC) 억제제입니다.

  • GC61758 structure
    GC61758Fluazifop-P-butyl
    CAS: 79241-46-6
    Purity: >98.50%

    아릴로페녹시프로피오네이트 그룹의 살사제인 Fluazifop-P-부틸은 아세틸-CoA 카르복실라제(ACCase) 억제제입니다.

  • GC64300 structure
    GC64300Haloxyfop
    CAS: 69806-34-4
    Purity: >98%

    Haloxyfop은 아릴옥시페녹시프로피온산 제초제이며 광엽작물의 풀 잡초에 널리 사용됩니다.

  • GC64681 structure
    GC64681VY-3-135
    CAS: 1824637-41-3
    Purity: >99.00%

    VY-3-135는 IC50 값이 44±3.85nM이고 수용성이 21.7μM인 강력하고 경구 투여가 가능한 ACSS2 억제제이다.

  • GC68587 structure
    GC68587A-908292
    CAS: 903886-95-3
    Purity: >99.00%

    A-908292는 효과적이고 선택적인 아세틸코엔자임 A 카복실라아제 2 (ACC2) 억제제로, hACC2의 IC50 값은 23 nM입니다. A-908292는 지방산 대사 연구에 사용될 수 있습니다.

  • GC68603 structure
    GC68603Acetyl-CoA Carboxylase-IN-1
    CAS: 179343-23-8
    Purity: >99.00%

    Acetyl-CoA Carboxylase-IN-1은 효과적인 아세틸코엔자임 A 카복실라제 (ACC) 억제제로, IC50 값은

  • GC70436 structure
    GC70436Propaquizafop
    CAS: 111479-05-1
    Purity: >98.00%

    Propaquizafop는 phenoxyisopropionic acid 제초제이자 acetyl-coA carboxylase 억제제입니다.

  • GC79177 structure
    GC79177AMPK activator 18
    CAS: 1364692-88-5
    Purity: >98.00%

    AMPK activator 18 is a potent allosteric activator of AMPK complexes containing the β2 isoform.

  • GC79552 structure
    GC79552XZA-1
    CAS: 1282141-20-1
    Purity: >99.50%

    XZA-1 is a 3-hydroxyacyl-coenzyme A dehydrogenase ( HADH ) activator.

  • GC79553 structure
    GC79553ACC1/2-IN-3
    CAS: 2131091-32-0
    Purity: >98.00%

    ACC1/2-IN-3 (example 66) is an ACC1 and ACC2 inhibitor with an IC 50 value of 1-10 nM for both.

  • GC79726 structure
    GC79726Selovoxolone
    CAS: 1786406-66-3
    Purity: >98.00%

    Selovoxolone (CKBA), a derivative of AKBA is an inhibitor of acetyl-CoA carboxylase 1 ( ACC1 ), with an IC 50 of 5.02 μM.