CP-640186 hydrochloride |
| Catalog No.GC35740 |
CP-640186 염산염은 쥐 간 ACC1 및 쥐 골격근 ACC2에 대해 각각 53nM 및 61nM의 IC50을 갖는 경구 활성 및 세포 투과성 아세틸-CoA 카르복실라제(ACC) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 591778-70-0
Sample solution is provided at 25 µL, 10mM.
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CP-640186 hydrochloride is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.
[1]. Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278(39):37099-111. [2]. Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.
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