ALLO-2 |
| Catalog No.GC34463 |
ALLO-2는 6 nM의 IC50으로 TM3-Gli-Luc 세포에서 Smo 작용제 Hh-Ag1.5 유도 루시퍼라제 발현을 억제하는 강력한 약물 내성 Smoothened(Smo) 돌연변이 길항제입니다.
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Cas No.: 1357350-60-7
Sample solution is provided at 25 µL, 10mM.
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ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM[1]. IC50: Smo[1].
[1]. Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18(4):432-7.
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