AZ-23 (AZ23) |
| Catalog No.GC33090 |
AZ-23(AZ23)은 2 nM(TrkA), 8 nM(TrkB), 24 nM(FGFR1), 52 nM(Flt3), 55의 IC50을 갖는 ATP 경쟁적이고 경구 생체이용 가능한 Trk 키나제 A/B/C 억제제입니다. nM(Ret), 84nM(MuSk), 99nM(Lck).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 915720-21-7
Sample solution is provided at 25 µL, 10mM.
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AZ-23 is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively.
AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC50 of 2 nM). AZ-23 Inhibits Trk-Dependent Survival in MCF10ATrkA-δ and TF-1 Cell Lines[1].
AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model and significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma[1].
[1]. Thress K, et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway. Mol Cancer Ther. 2009 Jul; 8(7):1818-27.
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