Carboplatin-d4 (Synonyms: CDDCA-d4, cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)-d4, CBDCA-d4) |
Catalog No.GC49286
One-Click Copy Product Info
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Carboplatin-d4(NSC 241240-d4)는 Carboplatin으로 표시된 중수소입니다. Carboplatin(NSC 241240)은 DNA에 결합하여 복제 및 전사를 억제하고 세포 사멸을 유도하는 DNA 합성 억제제입니다. Carboplatin(NSC 241240)은 CDDP의 유도체이며 강력한 항암제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Carboplatin-d4 is intended for use as an internal standard for the quantification of carboplatin by GC- or LC-MS. Carboplatin is a platinum-containing DNA-crosslinking agent.1 It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks when used at concentrations of 200 and 300 µM. It inhibits the proliferation of GLC-4 small cell lung carcinoma and A2780 and SKOV3 ovarian cancer cells (IC50s = 22.7, 0.5, and 10.2 µM, respectively).2,3 Carboplatin reduces tumor growth in an ADJ/PC6 murine plasmacytoma model (ED90 = 0.6 mg/kg, i.p.).4 Formulations containing carboplatin have been used in the treatment of ovarian cancer.
1.Micetich, K.C., Barnes, D., and Erickson, L.C.A comparative study of the cytotoxicity and DNA-damaging effects of cis-(diammino)(1,1-cyclobutanedicarboxylato)-platinum(II) and cis-diamminedichloroplatinum(II) on L1210 cellsCancer Res.45(9)4043-4047(1985) 2.Groen, H.J., Sleijfer, S., Meijer, C., et al.Carboplatin- and cisplatin-induced potentiation of moderate-dose radiation cytotoxicity in human lung cancer cell linesBr. J. Cancer72(6)1406-1411(1995) 3.Al-Eisawi, Z., Beale, P., Chan, C., et al.Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour modelsJ. Ovarian Res.6(1)78(2013) 4.Kelland, L.R., Abel, G., McKeage, M.J., et al.Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV): An orally active platinum drugCancer Res.53(11)2581-2586(1993)
| Cas No. | N/A | SDF | |
| Synonyms | CDDCA-d4, cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)-d4, CBDCA-d4 | ||
| Canonical SMILES | O=C([O-][Pt+2]1([NH3])[NH3])C2(C([2H])([2H])CC2([2H])[2H])C([O-]1)=O | ||
| Formula | C6H8D4N2O4Pt | M.Wt | 375.3 |
| Solubility | Methanol: slightly soluble,Water: slightly soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6645 mL | 13.3227 mL | 26.6454 mL |
| 5 mM | 532.9 μL | 2.6645 mL | 5.3291 mL |
| 10 mM | 266.5 μL | 1.3323 mL | 2.6645 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)