CAY10452 (Synonyms: PTPBS) |
| Catalog No.GC18427 |
CAY10452(화합물 3b)는 항염증 활성을 갖는 선택적 시클로옥시게나제-2(COX-2) 억제제(IC50=32 nM)입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 170569-87-6
Sample solution is provided at 25 µL, 10mM.
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Inhibitors of cyclooxygenase (COX) are generally grouped according to selectivity for COX-1 versus COX-2. However, many COX inhibitors also show an antitumor, pro-apoptotic activity that is distinct from COX inhibition - celecoxib is an example. CAY10452 is a celecoxib analog that retains potent, selective COX-2 inhibitory activity (IC50 = 32 nM), but does not induce apoptosis in prostate cancer cell lines even at 100 uM. CAY10452 is thus a clean, selective tool for the inhibition of COX-2.
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Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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