DHX8-IN-1 is a DHX8 inhibitor with an IC50 of 40 nM in ATPase activity assays. DHX8-IN-1 can be used in research on DHX8 -related diseases such as Dupuytren's contracture and HIV-1 infection [1].
In Vitro, DHX8 is an ATP-dependent RNA helicase whose core function is to participate in the splicing of mRNA precursors and to release mature mRNA from the spliceosome after splicing so that it can be exported from the nucleus to the cytoplasm for translation[1].
In Vitro, DHX8 is an ATP-dependent RNA helicase whose core function is to participate in the splicing of mRNA precursors and to release mature mRNA from the spliceosome after splicing so that it can be exported from the nucleus to the cytoplasm for translation[1].