Enpp/Carbonic andrase-IN-2 (compound 1i) is a potent Enpp and carbonic andrase inhibitor with IC50s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic andrase-IN-2 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic andrase-IN-2 induces Apoptosis.
Enpp/Carbonic andrase-IN-2 (compound 1i) (0-100 µM; ) inhibits some cancer cells growth with IC50s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, 0.83 µM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, T-47D cells, respectively[1].Enpp/Carbonic andrase-IN-2 (0-2 µM) shows low cytotoxic against normal breast epithelial cells (HME1) and normal skin fibroblast cells (F180) with IC50s of > 50 μM[1].Enpp/Carbonic andrase-IN-2 (0.58, 1.16 µM) induces apoptosis in a dose-dependent manner at K-562 cells[1].
References:
[1]. Afnan I.Shahin, et al. Design and synthesis of new adamantyl derivatives as promising antiproliferative agents. European Journal of Medicinal Chemistry, 2022.