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Factor Xa

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Factor Xa is a trypsin-like serine protease that catalyzes the cleavage of peptide bonds on the carboxyl side (P’1) of a basic amino acid residue with a preference to cleave peptide bonds of carboxyl function provided by an argininyl residue. Factor Xa plays an essential role in the coagulation cascade catalyzing the conversion of prothrombin to thrombin on surface of vascular cells to link the extrinsic and intrinsic pathways, in which it forms the Ca2+- and phospholipid-dependent prothrombinase complex with cofactor V/Va on activated platelets, monocytes or endothelial cells. Moreover, factor Xa has been found to mediate the stimulation of lymphocyte proliferation, induce the mitogenesis of endothelial and smooth muscle cells, and trigger acute inflammatory responses in vivo.

Products Related to Factor Xa(59)

  • GC17799 structure
    GC17799Betrixaban
    CAS: 330942-05-7
    Purity: >98.00%

    Betrixaban(PRT054021)은 IC50이 1.5nM인 매우 강력하고 선택적이고 경구적으로 효과적인 Xa 인자(fXa) 억제제입니다.

  • GC11101 structure
    GC111015-R-Rivaroxaban
    CAS: 865479-71-6
    Purity: >99.50%
  • GC11644 structure
    GC11644Edoxaban
    CAS: 480449-70-5
    Purity: >98.00%
  • GC12839 structure
    GC12839Edoxaban tosylate monohydrate
    CAS: 1229194-11-9
    Purity: >99.50%

    A potent inhibitor of Factor Xa

  • GC13130 structure
    GC13130Apixaban
    CAS: 503612-47-3
    Purity: >99.50%

    An inhibitor of Factor Xa

  • GC13683 structure
    GC13683Rivaroxaban
    CAS: 366789-02-8
    Purity: >99.50%

    A selective inhibitor of Factor Xa

  • GC13711 structure
    GC13711Gabexate mesylate
    CAS: 56974-61-9
    Purity: >98.00%

    A serine protease inhibitor

  • GC15757 structure
    GC15757Ozagrel
    CAS: 82571-53-7
    Purity: >99.50%

    A selective inhibitor of TXA synthase

  • GC17726 structure
    GC17726Otamixaban
    CAS: 193153-04-7
    Purity: >98.50%
  • GC18452 structure
    GC184523,4-Dichloroisocoumarin
    CAS: 51050-59-0
    Purity: >99.50%

    A serine protease inhibitor

  • GC19766 structure
    GC19766Heparin sodium salt (MW 15kDa)
    CAS: 9041-08-1

    헤파린나트륨염(MW 15kDa)(Sodium heparin(MW 15kDa))은 15kDa의 분자량을 갖는 헤파린의 중합체이다.

  • GC19839 structure
    GC19839Trypsin inhibitor(soybean) (≥4000 BAEE Units/mg)
    CAS: 9035-81-8

    Trypsin inhibitor(soybean) 는 IC 50 값이 19µM인 트립신 억제제이다. 또한 IC 50 값이 14.3µM로 칠모트립신을 억제할 수 있다.

  • GC25137 structure
    GC25137Betrixaban maleate
    CAS: 936539-80-9
    Purity: >98%

    Betrixaban maleate is the maleate salt form of Betrixaban, which is a Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.

  • GC32567 structure
    GC32567RWJ-445167 (3DP-10017)
    CAS: 226566-43-4
    Purity: >98%

    RWJ-445167(3DP-10017)(3DP-10017)은 강력한 항혈전 활성을 나타내는 Ki가 각각 4.0nM 및 230nM인 트롬빈 및 인자 Xa의 이중 억제제입니다.

  • GC32614 structure
    GC32614BMS-654457
    CAS: 1004551-41-0
    Purity: >98%

    BMS-654457은 각각 0.2 및 0.42nM의 Kis로 인간 및 토끼 FXIa와 결합하는 소분자, 인자 XIa(FXIa)의 가역적 억제제입니다.

  • GC35536 structure
    GC35536BMS-962212
    CAS: 1430114-34-3
    Purity: >98%

    BMS-962212는 직접적이고 가역적인 선택적 인자 XIa(FXIa) 억제제입니다.

  • GC35962 structure
    GC35962Edoxaban tosylate
    CAS: 480449-71-6
    Purity: >99.00%

    Edoxaban(DU-176b) 토실레이트는 자유 인간 FXa 및 프로트롬비나제에 대해 Kis가 0.561 및 2.98nM인 경구 활성, 매우 강력하고 선택적이며 직접적인 인자 Xa(FXa) 억제제입니다.

  • GC36092 structure
    GC36092FXIa-IN-1
    CAS: 1803271-50-2
    Purity: >98%

    FXIa-IN-1(화합물 EP-7041)은 강력한 β-락탐 공유 헤파린 유래 인자 XIa(fXIa) 억제제입니다.

  • GC36831 structure
    GC36831Ozagrel sodium
    CAS: 189224-26-8
    Purity: >99.50%

    오자그렐 나트륨(OKY-046 나트륨)은 트롬복산 A2(TXA2) 합성효소 억제제입니다.

  • GC40529 structure
    GC405297-hydroxy Warfarin
    CAS: 17834-03-6
    Purity: >98%

    7-hydroxy Warfarin is a metabolite of (-)-warfarin, which is a more potent vitamin K antagonist than (+)-warfarin.

  • GC43696 structure
    GC43696Fondaparinux (sodium salt)
    CAS: 114870-03-0
    Purity: >98.00%

    폰다파리눅스(나트륨염)는 항트롬빈 의존성 인자 Xa 억제제입니다.

  • GC44966 structure
    GC44966Sucrose octasulfate (potassium salt)
    CAS: 73264-44-5
    Purity: >95.00%

    Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.

  • GC45620 structure
    GC45620Bromadiolone
    CAS: 28772-56-7
    Purity: 95.00%

    An anticoagulant rodenticide

  • GC46863 structure
    GC46863Apixaban-13C-d3
    CAS: 1261393-15-0
    Purity: >99.00%

    Apixaban-13C-d3(BMS-562247-01-13C,d3)은 아픽사반으로 표시된 중수소 및 13C입니다.