FTBMT (Synonyms: FTBMT) |
| Catalog No.GC31071 |
FTBMT는 EC50이 75nM인 선택적 GPR52 작용제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1358575-02-6
Sample solution is provided at 25 µL, 10mM.
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FTBMT is a selective GPR52 agonist with an EC50 of 75 nM[1]. Antipsychotic and procognitive properties[2].
FTBMT (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50s of 7.03 6 0.04, 6.85 6 0.02, and 6.87 6 0.02[2].
FTBMT (30 mg/kg) exhibits antipsychotic-like activity without causing catalepsy in mice[2].
[1]. Tokumaru K, et al. Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg Med Chem. 2017 Jun 15;25(12):3098-3115. [2]. Nishiyama K, et al. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia. J Pharmacol Exp Ther. 2017 Nov;363(2):253-264.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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