Fusicoccin (Synonyms: NSC 113500) |
Catalog No.GC18611 |
곰팡이 파이토톡신인 Fusicoccin(Fusicoccin A)은 특정 14-3-3 단백질-단백질 상호작용의 안정제입니다. Fusicoccin은 바지의 H+-ATPase/14-3-3 cmplex를 안정화시켜 효소를 활성화 상태로 유지합니다. Fusicoccin은 또한 ERα, GPIbα, TASK3, CTFR 및 p53과 같은 C-말단 14-3-3 인식 모티프(모드 3 모티프)를 포함하는 결합 파트너와의 14-3-3 단백질 상호작용을 안정화합니다. Fusicoccin은 암세포에서 apoptosis를 유도하고 항암작용을 합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 20108-30-9
Sample solution is provided at 25 µL, 10mM.
Fusicoccin is a phytotoxin originally isolated from F. amygdali that induces death of tomato plants when used at concentrations ranging from 0.1 to 0.2 μg/ml. Topical administration of fusicoccin to tobacco (N. tabacum), sorghum (S. bicolor), cucumber (C. sativa), lucerne (M. sativa), and pokeweed (P. Americana) induces permanent opening of leaf stomata and wilting. Fusicoccin binds to the preformed complex between plasma membrane H+-ATPase and a 14-3-3 protein in plants to stabilize and activate the enzyme leading to dysregulated solute transport and control of transmembrane electric potential. It also stabilizes eukaryotic 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif, also known as a mode 3 motif, such as ERα, GPIbα, TASK3, CTFR, and p53 in vitro. Fusicoccin stimulates cortical neurite outgrowth in a 14-3-3 protein-dependent manner (EC50 = 29 μM). In vivo, topical administration of fusicoccin to the injury site reduces collapse and retraction of severed axons in a mouse model of spinal cord injury.
Review for Fusicoccin
Average Rating: 5
(Based on Reviews and 28 reference(s) in Google Scholar.)Review for Fusicoccin
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *