Sphinganine-1-phosphate (d18:0) (Synonyms: C18-dihydro Sphingosine-1-phosphate, D-erythro-Sphinganine-1-phosphate, dihydro-D-erythro-Sphingosine-1-phosphate) |
| Catalog No.GC44927 |
스핑가닌-1-포스페이트(d18:0)(D-에리트로-디하이드로스핑고신 1-포스페이트)는 세포 이동, 분화, 생존 및 복잡한 생리학적 과정을 조절하는 극성 스핑고지질 대사 산물입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 19794-97-9
Sample solution is provided at 25 µL, 10mM.
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Sphinganine-1-phosphate is an intermediate in the metabolism of glycosphingolipids and sphingolipids. It acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM). Sphinganine-1-phosphate prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses lower than 0.1 and 0.2 mg/kg when administered prior to or following reperfusion, respectively. It has antifibrotic effects in scleroderma fibroblasts through normalization of PTEN protein levels, collagen and matrix metalloproteinase-1 (MMP-1) expression, and Smad3 phosphorylation.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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