GC 14 |
| Catalog No.GC33794 |
GC 14는 선택적 갑상선 호르몬 수용체 길항제이며, hTRβ 및 hTRα에 대해 IC50 값이 각각 35nM 및 200nM입니다.
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Cas No.: 447415-34-1
Sample solution is provided at 25 µL, 10mM.
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GC 14 is a thyroid hormone antagonist.
GC 14 contains extensions at the 5′-position of the outer thyronine ring or from the bridging carbon and has only a modest affinity and potency for the thyroid hormone receptor (TR) that limits studies of their antagonistic actions[2].
[1]. Chiellini G, et al. Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives. Bioorg Med Chem. 2002 Feb;10(2):333-46. [2]. Nguyen NH, et al. Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem. 2002 Jul 18;45(15):3310-20.
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