A2764 dihydrochloride |
| Catalog No.GC39335 |
A2764 이염산염은 TRESK(TWIK 관련 척수 K+ 채널, K2P18.1)의 고도 선택성 억제제로, TREK-1 및 TALK-1에 중간 정도의 억제 효과가 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 861038-72-4
Sample solution is provided at 25 µL, 10mM.
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A2764 dihydrochloride is a highly selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1), which has moderate inhibitory effects on TREK-1 and TALK-1. A2764 dihydrochloride is more sensitive to the activated mTRESK channels (IC50=6.8 μM) than the basal current. A2764 dihydrochloride can lead to cell depolarization and increased excitability in native cells, it has the potential for probing the role of TRESK channel in migraine and nociception[1].
[1]. Lengyel M, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel.Mol Pharmacol. 2019 Jun;95(6):652-660.
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