Isoviolanthin |
| Catalog No.GC36349 |
플라보노이드 배당체인 이소비올란틴은 HCC 세포에서 TGF-β/Smad 및 PI3K/Akt/mTOR 경로를 통해 상피-중간엽 전이(EMT)를 비활성화함으로써 TGF-β1 매개 이동 및 침입을 현저하게 억제할 수 있습니다. Isoviolantin은 정상적인 간 LO2 세포에 대해 세포독성 효과를 나타내지 않습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 40788-84-9
Sample solution is provided at 25 µL, 10mM.
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Isoviolanthin is a flavonoid glycoside extracted from the leaves of Dendrobium officinale. Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells but exhibits no cytotoxic effects on normal live cells, and has potential as a therapeutic agent for the treatment of advanced-stage metastatic HCC[1].
[1]. Xing S, et al. Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial?Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways. Int J Mol Sci. 2018 May 23;19(6).
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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