JNJ-40411813 (ADX-71149) (Synonyms: ADX-71149) |
| Catalog No.GC30819 |
JNJ-40411813(ADX-71149)(ADX-71149)은 EC50이 147 nM인 대사성 글루타메이트 2 수용체(mGlu2R)의 새로운 양성 알로스테릭 조절제입니다.
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Cas No.: 1127498-03-6
Sample solution is provided at 25 µL, 10mM.
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JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.IC50 value: 147 nM(EC50)Target: mGlu2RJNJ-40411813 displayed an optimal interplay between potency, selectivity, favorable ADMET/PK and cardiovascular safety profile, and central EEG activity. JNJ-40411813 has been investigated in the clinic for schizophrenia and anxious depression disorders.
[1]. Cid JM, et al. Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor. J Med Chem. 2014 Aug 14;57(15):6495-512.
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