ML367 |
| Catalog No.GC36630 |
ML367은 ATPase 계열 AAA 도메인 함유 단백질 5(ATAD5) 안정화의 강력한 억제제이며 마이크로몰 억제 활성이 낮은 프로브 분자로 작용합니다. ML367은 DNA 복구 경로를 차단하고 UV 조사에 대한 반응으로 RPA32-인산화 및 CHK1-인산화를 포함한 일반적인 DNA 손상 반응을 억제합니다.
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Cas No.: 381168-77-0
Sample solution is provided at 25 µL, 10mM.
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ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1]. ATAD5[1]
ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd[1]. Western Blot Analysis[1] Cell Line: HEK293T cells
[1]. Rohde JM, et al. Discovery of ML367, inhibitor of ATAD5 stabilization. Probe Reports from the NIH Molecular Libraries Program.
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