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HCN Channel

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Hyperpolarization- and Cyclic Nucleotide-gated (HCN) channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channels. The HCN family consists of four members (HCN1-4). HCN channels represent the molecular correlates of I(h), a hyperpolarization-activated current best known for its role in controlling heart rate and in the regulation of neuronal resting membrane potential and excitability.

HCN channels are unique among vertebrate voltage-gated ion channels, in that they have a reverse voltage-dependence that leads to activation upon hyperpolarization. HCN channels are encoded by four genes (HCN1-4) and are widely expressed throughout the heart and the central nervous system.

Products Related to HCN Channel(9)

  • GC10578 structure
    GC10578ZD 7288
    CAS: 133059-99-1
    Purity: >98.00%

    ZD 7288은 과극화 활성화된 순환 뉴클레오타이드 (HCN) 채널 차단기이다.

  • GC16965 structure
    GC16965Zatebradine hydrochloride
    CAS: 91940-87-3
    Purity: >99.00%

    Zatebradine(UL-FS-49(유리 염기))은 IC50 값이 1.96μM인 과분극 활성화 순환 뉴클레오티드 게이트(HCN) 채널의 강력한 억제제입니다.

  • GC18503 structure
    GC18503DK-AH 269
    CAS: 186097-54-1
    Purity: >98.00%

    실로브라딘은 HCN 채널 차단제입니다. 뉴런 Ih 및 관련 심장 If 채널의 개방 채널 차단제.

  • GC32491 structure
    GC32491Zatebradine (UL-FS49)
    CAS: 85175-67-3
    Purity: >99.00%

    자테브라딘(UL-FS49)(UL-FS-49(유리 염기), UL-FS-49CL(유리 염기))은 IC50 값이 1.96 μ인 과분극 활성화 순환 뉴클레오티드 개폐(HCN) 채널의 강력한 억제제입니다. ;중.

  • GC68799 structure
    GC68799BPU-11
    CAS: 909664-41-1
    Purity: >98.00%

    BPU-11는 hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP 리간드입니다. BPU-11은 선천성 면역 질환 연구에 사용될 수 있습니다.

  • GC73927 structure
    GC73927KIO-301 chloride (hydrochloride)
    Purity: >99.00%

    KIO-301 chloride (hydrochloride) 는 과극화 활성화된 에폭시 뉴클레오티드 게이트와 전압 게이트 제어 칼륨 채널을 포함한 전압 게이트 제어 이온 채널을 차단하는 아조벤젠 광 스위치 화합물이다.

  • GC81721 structure
    GC81721Ivabradine
    CAS: 155974-00-8
    Purity: >99.50%

    Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If).

  • GC81722 structure
    GC81722pan-HCN-IN-1
    CAS: 1334308-63-2
    Purity: >99.50%

    pan-HCN-IN-1 is a potent HCN ion channel inhibitor with IC 50 values of 58 nM, 522 nM, 58 nM, and 58 nM against HCN1, HCN2, HCN3, and HCN4, respectively.

  • GC81726 structure
    GC81726VUANT1
    CAS: 663212-40-6
    Purity: >98.50%

    VUANT1 (VU0183254) is an allosteric antagonist of insect odorant receptor ion channels, which has the activity of inhibiting insect odorant receptor signaling.