VUANT1 (VU0183254) is an allosteric antagonist of insect odorant receptor ion channels, which has the activity of inhibiting insect odorant receptor signaling. VUANT1 can inhibit the activation of insect odorant receptors through allosteric regulation, which is important for the study of the molecular mechanism of insect olfactory signaling. Although it may be of limited use in insect control programs, it can be used as a pharmacological tool to study related mechanisms.
References:
[1]. Cuticular Hydrocarbon Pheromones for Social Behavior and Their Coding in the Ant Antenna
[2]. Allosteric antagonism of insect odorant receptor ion channels
References:
[1]. Cuticular Hydrocarbon Pheromones for Social Behavior and Their Coding in the Ant Antenna
[2]. Allosteric antagonism of insect odorant receptor ion channels