GLPBio

Hexokinase

Hexokinases phosphorylates glucose to generate glucose-6-phosphate, the initial step in glucose metabolism. HK1 and HK2 are two subtypes of mitochondrial hexokinases whichs are also involved in antiapopotic and cell survival.

Products Related to Hexokinase(6)

  • GC17430 structure
    GC174302-Deoxy-D-glucose
    CAS: 154-17-6
    Purity: >98.00%

    2-Deoxy-D-glucose (2DG)는 포도당 유사 물질로 경쟁적 당질 억제제로 작용한다.

  • GC11532 structure
    GC11532Lonidamine
    CAS: 50264-69-2
    Purity: >99.00%

    Lonidamine은 헥소키나아제, 미토콘드리아 피루베이트 수송체(고립된 쥐 간 미토콘드리아에서 Ki가 2.5μM) 및 원형질 막 단일 탄산 수송체의 억제제이고 미토콘드리아 복합체 II도 억제한다.

  • GC15523 structure
    GC155233-Bromopyruvic acid
    CAS: 1113-59-3
    Purity: >97.00%

    3-Bromopyruvic acid은 유산균해와 산화적 인산화를 억제할 수 있는 항종양제로 피루브산탈수소효소(PDH)와 이소시트르산탈수소효소(IDH)에 대한 IC50 값은 각각 15μM과 35μM이다.

  • GC27499 structure
    GC27499PROTAC HK2 Degrader-1
    CAS: 3033812-84-6
    Purity: >99.50%

    PROTAC HK2 Degrader-1 is a proteolysis-targeting chimera (PROTAC) targeting hexokinase 2 (HK2), generated by conjugating the HK2 inhibitor Lonidamine with the CRBN E3 ubiquitin ligase ligand Thalidomide via a linker.

  • GC70717 structure
    GC70717Benitrobenrazide (Hexokinase 2 inhibitor 1)
    CAS: 2454676-05-0
    Purity: >98.00%

    Benitrobenrazide (Hexokinase 2 inhibitor 1)는 HK2를 직접 표적화해서 해당과정을 억제한다.

  • GC79709 structure
    GC79709HK2-IN-4
    CAS: 2748366-80-3
    Purity: >99.50%

    HK2-IN-4 is a selective hexokinase 2 ( HK2 ) inhibitor with an IC 50 value of 0.79 μM and a K d value of 0.41 μM.