Lonidamine (Synonyms: AF 1890, DICA, Diclondazolic Acid) |
| Catalog No.GC11532 |
로니다민(AF-1890)은 헥소키나제 및 미토콘드리아 피루브산 담체 억제제(Ki: 2.5μM)입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 50264-69-2
Sample solution is provided at 25 µL, 10mM.
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Lonidamine (AF-1890), an antitumor agent, is a hexokinase, mitochondrial pyruvate carrier (Ki 2.5 μM in isolated rat liver mitochondria) and plasma membrane monocarboxylate transporters inhibitor, which also inhibits mitochondrial complex II[1][2].
References:
[1]. Guo L, et al. Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine. J Biol Chem. 2016 Jan 1;291(1):42-57.
[2]. Nancolas B, et al. The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. Biochem J. 2016 Apr 1;473(7):929-36.
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