3-Bromopyruvic acid (Synonyms: Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP) |
| Catalog No.GC15523 |
3-브로모피루브산(브로모피루브산)은 피루브산의 유사체이며 종양 선택성이 높은 강력한 헥소키나제(HK)-II 억제제입니다. 3-브로모피루브산은 해당과정을 방해하여 세포 성장을 억제하고 세포 사멸을 유도합니다. 3-브로모피루베이트는 유방암 세포에서 ROS 형성을 자극하여 자가포식을 유도합니다. 항균 활동.
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Cas No.: 1113-59-3
Sample solution is provided at 25 µL, 10mM.
3-Bromopyruvic acid is a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells.Target: hexokinase II in vitro: 3-BrPA dissociates HK II from this complex, causing cell death, and thus, having an anti-tumor effect. In vitro treatment of cells with 3-BrPA significantly inhibited their growth, as evaluated by MTT assay and adenosine triphosphate-tumor chemosensitivity assay (ATP-TCA). [1] 3-Bromopyruvic acid (3-BP) is a glycolytic inhibitor and a promising anticancer compound, induces oxidative stress and depletes cells of glutathione (GSH). [2]in vivo: 3-BrPA treatment (50 mg/kg ip. daily, 6 days/week for three weeks) is effective in the animal model by attenuating tumor growth and causing tumor necrosis. Toxic signs were not observed. The acute toxicity study provided an LD50 of 191.7 mg/kg for 3-BrPA. [1]
References:
[1]. Gong L, et al. 3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells : in vitro and in vivo findings. Anticancer Agents Med Chem. 2014 Jun;14(5):771-6.
[2]. Sadowska-Bartosz I, et al. Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione. Pharmacol Rep. 2016 Apr;68(2):502-5.
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