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HIV Protease

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Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.

Products Related to HIV Protease(35)

  • GC10240 structure
    GC10240Atazanavir sulfate (BMS-232632-05)
    CAS: 229975-97-7
    Purity: >99.50%

    An inhibitor of HIV-1 protease

  • GC10794 structure
    GC10794BMS-626529
    CAS: 701213-36-7
    Purity: >99.00%

    An HIV-1 attachment inhibitor

  • GC11300 structure
    GC11300Fosamprenavir Calcium Salt
    CAS: 226700-81-8
    Purity: >98.00%

    A prodrug form of amprenavir

  • GC11974 structure
    GC11974Pepstatin A
    CAS: 26305-03-3
    Purity: >98.50%

    Pepstatin A는 구강균에서 생산되는 아스파르타프로테아제 억제제로 경복하게 효율적이다.

  • GC12945 structure
    GC12945Atazanavir
    CAS: 198904-31-3
    Purity: >98%

    An inhibitor of HIV-1 protease

  • GC13716 structure
    GC13716Lopinavir
    CAS: 192725-17-0
    Purity: >99.00%

    A potent HIV-1 protease inhibitor

  • GC14084 structure
    GC14084Nelfinavir Mesylate
    CAS: 159989-65-8
    Purity: >99.00%

    HIV-1 프로테아제 억제제

  • GC14152 structure
    GC14152Amprenavir (agenerase)
    CAS: 161814-49-9
    Purity: >98.00%

    A selective HIV protease inhibitor

  • GC14454 structure
    GC14454Tipranavir
    CAS: 174484-41-4
    Purity: >98.00%

    A nonpeptidic HIV protease inhibitor

  • GC15335 structure
    GC15335Saquinavir
    CAS: 127779-20-8
    Purity: >99.00%
  • GC15785 structure
    GC15785Saquinavir mesylate
    CAS: 149845-06-7
    Purity: >98.50%

    An HIV protease inhibitor

  • GC16602 structure
    GC16602Darunavir
    CAS: 206361-99-1
    Purity: >99.50%

    An HIV-1 protease inhibitor

  • GC17303 structure
    GC17303Ritonavir
    CAS: 155213-67-5
    Purity: >99.50%

    An HIV protease inhibitor

  • GC17709 structure
    GC17709Nelfinavir
    CAS: 159989-64-7
    Purity: >99.00%

    Nelfinavir는 선택적, 비펩타이드성 HIV-1 프로테아제의 경쟁적 억제제이다. Nelfinavir는 HIV-1 균주에 대해 좋은 체외 활성을 보인다.

  • GC17942 structure
    GC17942Darunavir Ethanolate
    CAS: 635728-49-3
    Purity: >99.50%

    다루나비르 에탄올레이트(TMC114 Ethanolate)는 HIV/AIDS를 치료하고 예방하는 데 사용되는 강력한 HIV 프로테아제 억제제입니다.

  • GC32013 structure
    GC32013L-689502
    CAS: 138483-63-3
    Purity: >98%

    L-689502는 IC50이 1nM인 HIV-1 프로테아제의 강력한 억제제입니다.

  • GC32327 structure
    GC32327PNU-103017
    CAS: 166335-18-8
    Purity: >98%

    PNU-103017은 HIV 프로테아제 억제제입니다.

  • GC33968 structure
    GC33968DPC-681 (DPH-153893)
    CAS: 284661-68-3
    Purity: >99.50%

    DPC-681(DPH-153893)은 4~40nM의 야생형 HIV-1에 대한 IC90이 있는 HIV 프로테아제의 강력하고 선택적인 억제제입니다.

  • GC36116 structure
    GC36116Ganoderic acid B
    CAS: 81907-61-1
    Purity: >98.00%

    Ganoderic acid B는 버섯 Ganoderma lucidum에서 분리된 트리테르펜입니다.

  • GC36120 structure
    GC36120Ganodermanondiol
    CAS: 107900-76-5
    Purity: >98%

    Ganodermanondiol은 Ganoderma lucidum에서 분리된 멜라닌 생성 억제제입니다.

  • GC36309 structure
    GC36309Indinavir
    CAS: 150378-17-9
    Purity: >98%

    Indinavir(MK-639 유리 염기)는 PR에 대해 Ki가 0.54nM인 경구 활성 및 선택적 HIV-1 프로테아제 억제제입니다.

  • GC36310 structure
    GC36310Indinavir sulfate
    CAS: 157810-81-6
    Purity: >99.50%

    Indinavir 황산염(MK-639)은 PR에 대해 Ki가 0.54nM인 경구 활성 및 선택적 HIV-1 프로테아제 억제제입니다.

  • GC36333 structure
    GC36333Isoescin IA
    CAS: 219944-39-5
    Purity: >98.50%

    Isoescin IA는 Aesculus chinensis의 종자에서 분리된 트리테르페노이드 사포닌입니다.

  • GC36871 structure
    GC36871Pepstatin Ammonium
    Purity: >99.50%

    펩스타틴 암모늄은 헤모글로빈-펩신, 카제인-페프로타제, 카제인-펩신, 카제인-프로타제에 대해 IC50이 4.5nM, 6.2nM, 150nM, 290nM, 520nM 및 260nM인 방선균에 의해 생성된 특정 아스파르트산 프로테아제 억제제입니다. -산 프로테아제 및 헤모글로빈-산 프로테아제 각각.