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iAfaPhos1

Catalog No.GC81732 Copy One-Click Copy Product Info

iAfaPhos1 is a FKBP12F36V epimer ligand.

Products are for research use only. Not for human use. We do not sell to patients.

iAfaPhos1 Chemical Structure

Size 가격 재고 수량
1mg
US$439.00
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고객 리뷰

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.



Description of iAfaPhos1

iAfaPhos1 is a FKBP12F36V epimer ligand. iAfaPhos1 leads to reduced dephosphorylation of EGFR at pY1068 and pY845 sites. iAfaPhos1 has anticancer activity against non-small cell lung cancer [1].

References:
[1]. Hu Z, et al. EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Sci Adv. 2024 Mar 29;10(13):eadj7251.

Chemical Properties of iAfaPhos1

Cas No. SDF
Formula C64H77ClFN7O14 M.Wt 1222.79
Solubility Storage Store at -20°C
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of iAfaPhos1

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 817.8 μL 4.089 mL 8.178 mL
5 mM 163.6 μL 817.8 μL 1.6356 mL
10 mM 81.8 μL 408.9 μL 817.8 μL
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In vivo Formulation Calculator (Clear solution) of iAfaPhos1

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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