nAChR antagonist 3 is a selective α7 nAChR antagonist with an IC50 of 0.86 μM. nAChR antagonist 3 exerts a protective effect against paraoxon-induced toxicity. nAChR antagonist 3 can be used for the research of organophosphate poisoning [1].
In Vivo, nAChR antagonist 3 (Compound YZ4) (3 mg/kg; intravenous injection; single administration) exhibits a rescue effect against organophosphate poisoning in mice[1].
In Vitro, nAChR antagonist 3 (Compound YZ4) (3-30 μM; 24 h) exerts significant dose-dependent cytoprotective effects on HT22 cells treated with the organophosphorus pesticide Paraoxon[1].
References:
[1]. Zhang H, et al. Discovery of Potent and Subtype-Selective α7 nAChR Antagonists for Organophosphate Poisoning Protection. J Med Chem. 2026;69(5):6138-6157.
In Vivo, nAChR antagonist 3 (Compound YZ4) (3 mg/kg; intravenous injection; single administration) exhibits a rescue effect against organophosphate poisoning in mice[1].
In Vitro, nAChR antagonist 3 (Compound YZ4) (3-30 μM; 24 h) exerts significant dose-dependent cytoprotective effects on HT22 cells treated with the organophosphorus pesticide Paraoxon[1].
References:
[1]. Zhang H, et al. Discovery of Potent and Subtype-Selective α7 nAChR Antagonists for Organophosphate Poisoning Protection. J Med Chem. 2026;69(5):6138-6157.