NPD-001 |
| Catalog No.GC64844 |
NPD-001은 각각 4 및 3 nM의 IC50 값을 갖는 강력한 Trypanosoma brucei phosphodiesterases TbrPDEB1 및 TbrPDEB2 억제제입니다.
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Cas No.: 469863-16-9
Sample solution is provided at 25 µL, 10mM.
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NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC50 of 80 nM[1].
[1]. Veerman J, et al. Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals. Bioorg Med Chem. 2016 Apr 1;24(7):1573-81.
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