Pancreatic Polypeptide, rat TFA

Pancreatic Polypeptide, rat TFA (Rat pancreatic polypeptide TFA) is a rat-derived Pancreatic Polypeptide. Pancreatic Polypeptide is a preferential agonist of NPYR4. Pancreatic Polypeptide, rat TFA protects cells against Streptozotocin -induced DNA damage. Pancreatic Polypeptide, rat inhibits glucose-stimulated insulin secretion. Pancreatic Polypeptide, rat (TFA) can be used in diabetes-related research ^{[1] [2]}.

In Vitro, Pancreatic Polypeptide, rat (0.1 μM-1 μM) TFA inhibits glucose-stimulated insulin secretion in rat BRIN BD11 β-cells, with no effect at lower concentrations or under basal glucose levels^[2]. Pancreatic Polypeptide, rat (1 μM; 2 h) TFA completely protects rat BRIN BD11 β-cells against Streptozotocin -induced DNA damage^[2].

References:
[1]. Kimmel JR, et al. Pancreatic polypeptide from rat pancreas. Endocrinology. 1984 May;114(5):1725-31.
[2]. Khan D, et al. Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival. Biochimica et biophysica acta. General subjects. 2017 Apr;1861(4):749-758.