Phenytoin-d10 is a deuterium-labeled phenytoin used as an isotopic tracer. Phenytoin-d10 can serve as an internal standard in GC‑MS or LC‑MS analysis for the quantitative determination of phenytoin. Phenytoin exhibits antiepileptic activity and can reduce the growth and metastasis of breast tumors. Phenytoin-d10 can be applied in studies related to drug metabolism research, as well as the development and validation of quantitative analytical methods[1-4].
References:
[1] Garg U, Peat J, Frazee C 3rd, et al. A simple isotope dilution electrospray ionization tandem mass spectrometry method for the determination of free phenytoin. Ther Drug Monit. 2013 Dec;35(6):831-5.
[2] Russak EM, Bednarczyk EM. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
[3] Nelson M, Yang M, Dowle AA, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 27;14(1):13.
[4] Rogawski MA, Löscher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci. 2004 Jul;5(7):553-64.