GLPBio

PROTAC CDK6 Degrader 1

Catalog No.: GC80885Purity:>98.50%
COASDSData Sheet
PROTAC CDK6 Degrader 1 (compound 48a) is a potent and selective PROTAC CDK6 degrader with a DC50 of 0.037 μM.

제품은 연구용으로만 사용됩니다. 인체에 사용할 수 없으며 환자에게 판매하지 않습니다.

PROTAC CDK6 Degrader 1
5mgIn Stock
$1,377.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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제품 설명 (Description)

PROTAC CDK6 Degrader 1 (compound 48a) is a potent and selective PROTAC CDK6 degrader with a DC50 of 0.037 μM. PROTAC CDK6 Degrader 1 exhibits selectivity over CDK4 ( DC50 > 10 μM). PROTAC CDK6 Degrader 1 induces G0/G1 cell-cycle arrest and apoptosis through inhibition of CDK6 downstream signaling. PROTAC CDK6 Degrader 1 reduces tumor burden and CDK6 levels in a MOLM-14 xenograft mouse model. PROTAC CDK6 Degrader 1 can be used for CDK6-driven cancers research, such as acute myeloid leukemia (AML) [1]. (Pink: CDK6 ligand; Blue: KLHDC2 ligand; Black: linker).

References:
[1]. Jeon E, et al. Selective CDK6 Degradation via the KLHDC2 E3 Ubiquitin Ligase. J Med Chem. 2025 Dec 11;68(23):25539-25568.

제품 문서 (Product Documents)

Purity:>98.50%Appearance:A solid
COASDSData Sheet

화학적 특성 (Chemical Properties)

분자식
C70H89N15O8
분자량
1268.55
용해도
DMSO: 50 mg/mL (39.42 mM; Need ultrasonic)
보관
Store at -80°C, protect from light
배송 조건
평가용 샘플은 아이스팩과 함께 배송됩니다. 그 외 용량은 실온 배송되며, 요청 시 아이스팩과 함께 배송할 수 있습니다.

계산 도구 (Calculators)몰 농도 / 희석 / 분자량 / 단위 변환 / 생체 내 제형 / 용해도

g/mol

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