Enzymes

PTPN2/1-IN-2 는 다양한 종양 연구에 사용할 수있는 PTPN2/1 옹색제입니다.

PP5-IN-1 (화합물 P053)은 세린/트레오닌 단백질 phosphatase-5 (PP5)의 경쟁력 있는 억제제로 촉매 영역에 결합하여 신장암에서 세포 사멸을 유발합니다.

LYP-IN-3 (복합 D34)는 선별적 억제 제야의 Lymphoid-tyrosine phosphatase (LYP) (기성 = 93 μ M),하고 t 세포 수용체를 조절 한 진행 경로 (TCR) 신호 종양 입니다.

MMP-7-IN-3은 MMP-7의 강력하고 선택적 억제제이다.

MMP-9/10-IN-2 (화합물 6e) 는 MMP10과 MMP9의 강력한 억제제로서 MMP10에 대한 IC50은 0.076μM, MMP9에 대한 IC50은 0.5μM일 때 억제율은 93.18% 이다.

BPU 이하 g1단계에서 세포주기 진행을 저지한다.

(R)-Azasetron besylateSENS-401은 경구 활성 칼슘 조신경 인산 효소 억제제다.

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is a fluorescently quenched peptide substrate that can be used to detect the activity of matrix metalloproteinases (MMPs) and their associated tumor necrosis factor converting enzyme (TACE) (Ex/Em=325nm/400nm).

AV5116 is a cap-dependent endonuclease inhibitor ( CENI ) that binds to the active site of the cap-dependent endonuclease (CEN) located in the N-terminal domain of the polymerase acidic.

Cusculine (FAC21) is an oropouche virus (OROV) endonuclease inhibitor with an IC 50 of 1.4 μM.

Snail IN-1 is an orally active Snail inhibitor with a Ka of 0.36 μM.Snail IN-1 disrupts Snail - CBP interaction, accelerates Snail protein degradation, reduces Snail acetylation, increases Snail polyubiquitination, and selectively downregulates Snail protein without altering other EMT transcription factors.Snail IN-1 reduces atherosclerotic plaque burden, modulates inflammation and plaque stability factors, downregulates CCL5, CXCL10, MMP2, and MMP9, and upregulates α-smooth muscle actin.Snail IN-1 exerts anti-inflammatory and plaque-stabilizing properties.Snail IN-1 can be used for the research of atherosclerosis [1] .

BBO-11818 is an orally active, highly selective (relative to NRAS and HRAS ), non-covalent pan- KRAS inhibitor ( IC 50 =28-120 nM).

RM-046 is an orally active, selective ternary complex inhibitor of KRAS Q61H (active form).

CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor ( CCKBR ) agonist with an EC 50 of 35 pM.

ZX-J-19L is a CyPJ inhibitor with inhibitory activity against a variety of tumor cell lines.

DKFZ-251 is a kininogenase-related peptidase KLK6 inhibitor ( IC 50 =0.47 μM), and also exhibits certain inhibitory activity against KLK5 and KLK7 ( IC 50 values are 1.1 nM and 73 nM, respectively).

KVD-001 is a potent plasma kallikrein inhibitor.

IL13Rα2 D1 is an effective IL-13/IL13Rα2 signaling axis inhibitor.

PFKFB4-IN-1 is a potent and selective ATP-competitive PFKFB4 inhibitor ( IC 50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels.

PTPRO-IN-1 is a selective, orally active PTPRO inhibitor with an IC 50 of 0.16 μM.

Royleanonic acid is an abietan-type diterpene found in the leaves of Salvia officinalis L.

LacCer (d18:1/20:0) is a lipid whose level is closely associated with atherosclerosis and cardiovascular diseases [1] .

MMP-9-IN-13 (Example 1) is a selective inhibitor of human MMP9 with an IC 50 value of 0.02 nM.

C-telopeptide acetate is a cross-linked peptide of type I collagen that is released during bone resorption and correlates with bone mineral density (BMD).