QX77 |
| Catalog No.GC32962 |
QX77은 샤페론 매개 자가포식(CMA) 활성제이며 시험관 내에서 LAMP2A 발현을 상향 조절합니다. QX77은 Rab11 상향 조절을 유도하고, 시스틴 세포에서 Rab11 하향 조절 및 인신매매 결핍을 구제합니다. QX77은 자가 재생을 방해하고 ES 세포의 분화를 촉진할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1798331-92-6
Sample solution is provided at 25 µL, 10mM.
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QX77 is a chaperone-mediated autophagy (CMA) activator.
Treatment with CMA activator QX77 rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 treatment also increases LAMP2A localization at the lysosomal membrane[1].
[1]. Zhang J, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 Jun 23;292(25):10328-10346.
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