Pain Research

LY2183240 is a potent, competitive small molecule inhibitor of anandamide uptake (IC50 = 270 pM; Ki = 540 pM) and hydrolysis.

(±)13(14)-EpDPA(13,14-EpDPE)는 시토크롬 P-450 에폭시게나제와 도코사헥사엔산(DHA)의 반응 생성물입니다.

Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina.

N-desmethyl Zolmitriptan (DZT) is an active metabolite of the serotonin (5-HT) receptor subtype 5-HT1B and 5-HT1D agonist zolmitriptan.

α-Phellandrene is a cyclic monoterpene that has been found in various plants, including Cannabis, and has diverse biological activities.

URB754는 IC50이 200nM인 체내칸나비노이드 비활성화 효소 모노아실글리세롤 리파제(MGL)의 강력한 억제제입니다.

(±)-WIN 55,212-2 is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki value of 62.3 and 3.3 nM for human recombinant central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, respectively.

(Ala1)-PAR4 (1-6) amide (mouse) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that induces aggregation of rat and human platelets in vitro (EC50s = 15 and 60 μM, respectively).

An acetaminophen-protein adduct

4-hydroxy (S)-Duloxetine β-D-glucuronide is an inactive metabolite of the serotonin and norepinephrine reuptake inhibitor (S)-duloxetine.

5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine.

6-hydroxy Chlorzoxazone은 체내에서 클로르조사존의 주 대사 산물이다. 6-hydroxy Chlorzoxazone은 주로 간 세포색소 P450 효소계를 통해 형성되고 생화학 연구에서 CYP2E1 활성을 정량적으로 평가하기 위한 프로브로 일반적으로 사용된다.

Acetaminophen glucuronide is an inactive metabolite of the analgesic and antipyretic agent acetaminophen.

Acetaminophen sulfate is a metabolite of acetaminophen.

Acetyl β-endorphin is an acetylated derivative of β-endorphin that binds to opioid receptors in rat caudal dorsomedial medulla (Ki = 490 nM) and mouse brain membrane preparations (IC50 = 109 nM).

Angiotensin II (3-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II.

AT-121은 3.67 및 16.49 nM의 Kis를 갖는 이기능성 통각 및 뮤 오피오이드 수용체 작용제이다.

The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes.

Biocytin-β-endorphin is a form of β-endorphin that is conjugated to biocytin.

부피바카인은 NMDA 수용체 억제제입니다.

Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper.

Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons.

CCR4 antagonist is an antagonist of CC chemokine receptor 4 (CCR4) that inhibits human CCL22-derived [35S]GTPγS and [125I]CCL22 binding in vitro (IC50s = 19 and 70 nM, respectively).

CTAP is a water soluble, cyclic octapeptide which acts as a receptor antagonist that is selective for the μ opioid receptor (IC50 = 3.5 nM) over the δ receptor (IC50 = 4,500 nM).