(±)13(14)-EpDPA (Synonyms: (±)13,14-EDP, (±)13,14-EpDPE, (±)13,14-epoxy DPA, (±)13,14-epoxy Docosapentaenoic Acid) |
| Catalog No.GC41191 |
(±)13(14)-EpDPA(13,14-EpDPE)는 시토크롬 P-450 에폭시게나제와 도코사헥사엔산(DHA)의 반응 생성물입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 895127-64-7
Sample solution is provided at 25 µL, 10mM.
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Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 13,14-double bond of DHA. It has been detected in rat brain and spinal cord and is a preferred substrate for soluble epoxide hydrolase with a Km value of 3.2 µM. (±)13(14)-EpDPA demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models. (±)13(14)-EpDPA and other epoxy metabolites of DHA are also reported to potently inhibit angiogenesis and tumor growth in in vitro assays.
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