Reactive Oxygen Species
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Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.
ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Products Related to Reactive Oxygen Species(505)
- GC72791Delmitide acetateCAS: 501019-16-5Purity: >98.00%
Delmitide acetate 는 구복 활성 d-이구체 십펩타이드로 강력한 항염 활성을 가지고 있다.
- GC72858Avenanthramide ACAS: 108605-70-5Purity: >99.00%
Avenanthramide A은 귀리(Avena sativa L.)에서 발견할 수 있는 ptoalexin의 일종이다.
- GC72995MnTE-2-PyP chlorideCAS: 219818-60-7Purity: >95.00%
MnTE-2-PyP chloride는 ROS 스캐빈저 및 강력한 방사선 보호기입니다.
- GC73031Salpyran dihydrochloridePurity: >99.00%
Salpyran dihydrochloride 는 치료 잠재력이 있는 Cu (II) 선택적 집게발이다.
- GC73225ROS-generating agent 1CAS: 2369030-41-9Purity: >99.00%
ROS-generating agent 1 (화합물 2c)는 TrxR의 Sec-498잔류물을 공유적으로 변형시켜 ROS를 생성한다.
- GC74090Dimethyl fumarate-d2CAS: 23057-98-9Purity: >99.00%
Dimethyl fumarate-d2 는 듀테륨 표기의 부마산 디메틸에스테르입니다.
- GC746683-Methoxy-9H-CarbazoleCAS: 18992-85-3Purity: >99.00%
3-Methoxy-9H-Carbazole 카스파스-3 활성과 세포의 활성산소 생성을 유도한다.
- GC81540Brevicidine TFAPurity: >97.50%
Brevicidine TFA is an antimicrobial peptide with selective bactericidal activity against Gram-negative pathogens.
- GC81541BMAP-27 acetatePurity: >98.00%
BMAP-27 acetate is a cationic amphipathic α-helical antimicrobial peptide with anticancer activity.
- GC815427-O-Galloyl-D-sedoheptuloseCAS: 233690-85-2Purity: >98%
7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound.
- GC81543GPX4-IN-19CAS: 3102894-57-2Purity: >99.00%
GPX4-IN-19 is an effective GPX4 inhibitor ( IC 50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4.
- GC81544Copper ionophore ICAS: 101264-90-8Purity: >98.00%
Copper ionophore I is an efficient copper ion carrier.
- GC81545Ferroptosis inducer-12Purity: >96.00%
Ferroptosis inducer-12 is a potent and selective ferroptosis inducer.
- GC81547Geranyl isovalerateCAS: 109-20-6Purity: >96.50%
Geranyl isovalerate is a chemical component that can be extracted from Argyreia Nervosa.
- GC81548CIGB-552 TFAPurity: >98.00%
CIGB-552 TFA is a cell-penetrating peptide with anti-tumor properties with the IC 50 of 23 μM in H460 cells.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC72755 | Tempol-d17,15N | 90429-66-6 | - | |
Tempol-d17,15N 는 듀테륨 태그의 Tempol입니다. | ||||
| GC72791 | Delmitide acetate | 501019-16-5 | >98.00% | |
Delmitide acetate 는 구복 활성 d-이구체 십펩타이드로 강력한 항염 활성을 가지고 있다. | ||||
| GC72858 | Avenanthramide A | 108605-70-5 | >99.00% | |
Avenanthramide A은 귀리(Avena sativa L.)에서 발견할 수 있는 ptoalexin의 일종이다. | ||||
| GC72888 | CPS-11 | 145945-21-7 | >99.00% | |
CPS-11 (N-(droxymetl) 샤를리도민) 는 샤를리도민 유사물로 강력한 항암제이다. | ||||
| GC72995 | MnTE-2-PyP chloride | 219818-60-7 | >95.00% | |
MnTE-2-PyP chloride는 ROS 스캐빈저 및 강력한 방사선 보호기입니다. | ||||
| GC73031 | Salpyran dihydrochloride | - | >99.00% | |
Salpyran dihydrochloride 는 치료 잠재력이 있는 Cu (II) 선택적 집게발이다. | ||||
| GC73188 | SFI003 | 2361332-90-1 | >99.00% | |
SFI003은 SRSF3/DHCR24/ROS 축을 통해 CRC 세포 사멸을 추진하고 in vitro와 in vivo에서 모두 강력한 항암 효과를 나타내는 SRSF3억제제이다. | ||||
| GC73212 | TH-6 | 3031349-25-1 | >95.00% | |
TH-6 는 강력한 HDAC 억제제로서 HDAC1, HDAC2, HDAC3, HDAC6, HDAC8의 IC50은 각각 0.115, 0.135, 0.242, 0.138, 2.120 µM이다. | ||||
| GC73225 | ROS-generating agent 1 | 2369030-41-9 | >99.00% | |
ROS-generating agent 1 (화합물 2c)는 TrxR의 Sec-498잔류물을 공유적으로 변형시켜 ROS를 생성한다. | ||||
| GC73543 | FC-116 | 2417298-29-2 | >98.00% | |
FC-116 는 쥐의 종양 성장을 효과적으로 억제하는 미관 단백질 억제제이다. | ||||
| GC74090 | Dimethyl fumarate-d2 | 23057-98-9 | >99.00% | |
Dimethyl fumarate-d2 는 듀테륨 표기의 부마산 디메틸에스테르입니다. | ||||
| GC74256 | Condurango glycoside A | 11051-90-4 | >95.00% | |
Condurango glycoside A 는 p53의 활성제입니다. | ||||
| GC74270 | Penduletin | 569-80-2 | >99.00% | |
Penduletin 는 플라스마와 가시나무에서 분리 될 수있는 플라보노이드 화합물입니다. | ||||
| GC74668 | 3-Methoxy-9H-Carbazole | 18992-85-3 | >99.00% | |
3-Methoxy-9H-Carbazole 카스파스-3 활성과 세포의 활성산소 생성을 유도한다. | ||||
| GC81540 | Brevicidine TFA | - | >97.50% | |
Brevicidine TFA is an antimicrobial peptide with selective bactericidal activity against Gram-negative pathogens. | ||||
| GC81541 | BMAP-27 acetate | - | >98.00% | |
BMAP-27 acetate is a cationic amphipathic α-helical antimicrobial peptide with anticancer activity. | ||||
| GC81542 | 7-O-Galloyl-D-sedoheptulose | 233690-85-2 | >98% | |
7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound. | ||||
| GC81543 | GPX4-IN-19 | 3102894-57-2 | >99.00% | |
GPX4-IN-19 is an effective GPX4 inhibitor ( IC 50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4. | ||||
| GC81544 | Copper ionophore I | 101264-90-8 | >98.00% | |
Copper ionophore I is an efficient copper ion carrier. | ||||
| GC81545 | Ferroptosis inducer-12 | - | >96.00% | |
Ferroptosis inducer-12 is a potent and selective ferroptosis inducer. | ||||
| GC81546 | iMQT_020 | 2463893-46-9 | >99.00% | |
iMQT_020 is a selective allosteric SLC1A5_var inhibitor. | ||||
| GC81547 | Geranyl isovalerate | 109-20-6 | >96.50% | |
Geranyl isovalerate is a chemical component that can be extracted from Argyreia Nervosa. | ||||
| GC81548 | CIGB-552 TFA | - | >98.00% | |
CIGB-552 TFA is a cell-penetrating peptide with anti-tumor properties with the IC 50 of 23 μM in H460 cells. | ||||
| GC81553 | YRDC-IN-1 | 3120494-74-5 | >93.50% | |
YRDC-IN-1 is a blood-brain barrier-permeable YRDC inhibitor. | ||||