TH-6 |
Catalog No.GC73212
One-Click Copy Product Info
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TH-6 는 강력한 HDAC 억제제로서 HDAC1, HDAC2, HDAC3, HDAC6, HDAC8의 IC50은 각각 0.115, 0.135, 0.242, 0.138, 2.120 µM이다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3031349-25-1
Sample solution is provided at 25 µL, 10mM.
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TH-6 is a potent HDAC inhibitor with IC50s of 0.115, 0.135, 0.242, 0.138, 2.120 µM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively. TH-6 inhibits cell migration and invasion. TH-6 induces apoptosis and cell cycle arrest at G2/M phase. TH-6 shows anti-tumor activity.
TH-6 (0-2 µM) shows antiproliferative activities in cancer cell lines and normal human lung cells[1].TH-6 (0-10 µM) inhibits tubulin polymerization with an IC50 value of 4.06 µM[1].TH-6 (0.03, 0.1, 0.3 1 µM; 24 h) increases the expression of Ac-α-Tubulin and AC-Histone H3 in HepG2 cells[1].TH-6 (7.5, 15, 30 nM) induces apoptosis and cell cycle arrest at G2/M phase[1].TH-6 (0-30 nM) decreases the MMP and increase ROS levels of HepG2 cells in a dose-dependent manner[1].TH-6 (7.5, 15, 30 nM; 48 h) inhibits cell migration and invasion in MDA-MB-231 cells and suppress the migration of HUVECs in a concentration-dependent manner[1].TH-6 shows favorable liver microsomal stability in vitro with t1/2 of 50.3 min[1].
TH-6 (10, 20 mg/kg; i.v.; daily for 21 days) shows anti-tumor activity in mouse[1].TH-6 (20 mg/kg) shows antivascular activity and a good cardiovascular safety profile in mouse[1].
References:
[1]. Zhu H, et al. Discovery of a Novel Vascular Disrupting Agent Inhibiting Tubulin Polymerization and HDACs with Potent Antitumor Effects. J Med Chem. 2022 Aug 4.
| Cas No. | 3031349-25-1 | SDF | |
| Formula | C22H24FN3O5 | M.Wt | 429.44 |
| Solubility | DMSO : 50 mg/mL (116.43 mM; ultrasonic and warming and heat to 60°C) | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3286 mL | 11.6431 mL | 23.2861 mL |
| 5 mM | 465.7 μL | 2.3286 mL | 4.6572 mL |
| 10 mM | 232.9 μL | 1.1643 mL | 2.3286 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)