S119-8 |
| Catalog No.GC32222 |
S119-8은 A형, B형 인플루엔자 바이러스에 대한 광범위한 억제제로, 여러 인플루엔자 B 바이러스와 오셀타미비르 내성 인플루엔자 A 바이러스에 대해 활성을 보이지만 비인플루엔자 바이러스인 수포성 구내염(VSV)은 억제하지 못한다 .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 443639-96-1
Sample solution is provided at 25 µL, 10mM.
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S119-8 is a broad spectrum inhibitor of influenza A and B viruses.
S119-8 is an analog of S119. S119-8 has acquired enhanced broad-spectrum activity with improved calculated physical properties, while maintaining significant potency (IC50=1.43 μM) at non-toxic (CC50=66.10 μM) concentrations, albeit somewhat higher (7-fold) than that of the parent S119 against influenza A/WSN/33 H1N1 (WSN) virus. S119-8 also shows activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV). S119-8 has increased breadth of inhibition against influenza A and B viruses accompanied by only a small loss in potency. S119-8 inhibits influenza viruses A/Puerto Rico/8/1934 (H1N1) (PR8) with an IC50 of 6.05 μM. S119-8 inhibits influenza A/Vietnam/1203/2004 (H5N1) with an IC50 of 8.42 μM[1].
[1]. White KM, et al. Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. ACS Infect Dis. 2018 Feb 9;4(2):146-157.
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