S3969 |
Catalog No.GC70343
One-Click Copy Product Info
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S3969은 인간 상피 나트륨 채널 (hENaC)의 강력하고 가역적인 활성제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1027997-01-8
Sample solution is provided at 25 µL, 10mM.
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S3969 fully and reversibly activates hENaC in heterologous cells. S3969 activates δβγ, αβγ, α2βγ, δ2βγ, and αβG37Sγ hENaC with EC50s of 1.2±0.2 μM, 1.2±0.1 μM, 1.2±0.5, 0.4±0.1,and 1.2±0.4 μM[1].
S3969 does not activate αβγ mouse ENaC (mENaC) at concentrations yielding maximal activation of αβγ hENaC or δβγ hENaC. Weak αβγ mENaC activation was observed at high concentrations of S3969 (100-300 μm)[1].
S3969 exhibits high efficacy (600-700% hENaC activation at 30 μm) as well as potency on wild-type hENaC (apparent EC50 ∼1 μm for αβγ hENaC and δβγ hENaC but not αβγ mENaC) [1].
ENaC-activator S3969 (10 µM) stimulates αF61L mutant ENaC more than wild-type ENaC[2].
References:
[1]. Min Lu, et al. Small molecule activator of the human epithelial sodium channel. J Biol Chem. 2008 May 2;283(18):11981-94.
[2]. Regina Huber, et al. Functional characterization of a partial loss-of-function mutation of the epithelial sodium channel (ENaC) associated with atypical cystic fibrosis. Cell Physiol Biochem. 2010;25(1):145-58.
| Cas No. | 1027997-01-8 | SDF | |
| Formula | C17H24N2O2S | M.Wt | 320.45 |
| Solubility | DMSO : 100 mg/mL (312.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.1206 mL | 15.6031 mL | 31.2061 mL |
| 5 mM | 624.1 μL | 3.1206 mL | 6.2412 mL |
| 10 mM | 312.1 μL | 1.5603 mL | 3.1206 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)