Other Signal Transduction

GATA4-NKX2-5-IN-1 (3i-1000) is a small-molecule compound inhibiting GATA4 and NKX2-5 transcriptional synergy with IC50 of 3 uM

Panx-1 mimetic inhibitory peptide, blocks pannexin-1 gap junctions

Eeyarestatin I는 강력한 내지질망 관련 단백질 분해(ERAD) 억제제이고 강력한 단백질 전이 억제제이다. 소포체 (ER) 항상성을 혼란시키고 Bortezomib과 유사한 항암활성을 가지고 있다. Eeyarestatin I는 Sec61 전위구를 억제한다.

10Panx is a potent Panx1 channel inhibitor that targets the W74 to Y83 segment of the ECL1 of Panx1 protein.

항간질제인 레베티라세탐은 시냅스 소포 단백질 SV2A에 결합합니다.

BLU-782는 경구 활성을 가진 액티비닌 수용체 유사 활성효소 2 (ALK2) 억제제로 ALK2R206H, ALK2, ALK1, ALK6, ALK3, ALK4 및 ALK5에 대한 IC50 값은 각각 0.2nM, 0.6nM, 3nM, 24nM, 45nM, 65nM 및 155nM이다.

M2N12는 IC50 값이 0.09μM인 강력하고 고도로 선택적인 세포 분열 주기 25C 단백질 포스파타제(Cdc25C) 억제제입니다. M2N12는 또한 각각 0.53μM 및 1.39μM의 IC50 값으로 Cdc25A 및 Cdc25B에 대해 유망한 활성을 가지고 있습니다. M2N12는 항종양 활성이 있어 암 연구에 사용할 수 있습니다.

LP-935509는 어댑터 단백질-2 연관 키나아제 1 (AAK1)의 구강 흡수, 강력한 선택적 ATP 경쟁적 및 뇌 침투성 억제제로서 IC50가 3.3 nM이고 Ki가 각각 0.9 nM입니다.

Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.

Compound 43 TAO kinase inhibitor is an ATP-competitive inhibitor of the thousand-and-one amino acid kinases TAOK1 and TAOK2 (IC50s = 11 and 15 nM, respectively).

Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.

D-myo-inositol-1,2,3,5,6-pentaphosphate (Ins(1,2,3,5,6)-P5) (sodium salt) is produced from Ins(1,2,3,4,5,6)P6 via a minor enzymatic phytate degradation pathway by K.

D-myo-Inositol-1,2,3,5-tetraphosphate (Ins(1,2,3,5)P4) is one of the many inositol phosphate isomers that could act as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1,2,4,5,6-pentaphosphate (sodium salt) (Ins(1,2,4,5,6)P5 (sodium salt)) is one of several different inositol oligophosphate isomers implicated in signal transduction.

Ins(1,2,4,5)P4 is one of the many inositol phosphate (InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals..

D-myo-Inositol-1,2,6-phosphate (Ins(1,2,6)-P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.

The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents.

The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals.

D-myo-Inositol-1,3,5-phosphate (Ins(1,3,5)P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.

D-myo-Inositol-1,4-phosphate (Ins(1,4)P2) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1,5-phosphate (Ins(1,5)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate molecular family of second messengers that play critical roles in intracellular signaling.

D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate (InsP) molecular family of second messengers that play a critical role in the transmission of cellular signals.

D-myo-inositol-2,3,5,6-tetraphosphate (sodium salt) (Ins(2,3,5,6)-P4 (sodium salt)) is produced from Ins(1,2,3,5,6)P5 via a minor enzymatic phytate degradation pathway by K.