LP-935509 |
Catalog No.GC39256 |
LP-935509는 어댑터 단백질-2 연관 키나아제 1 (AAK1)의 구강 흡수, 강력한 선택적 ATP 경쟁적 및 뇌 침투성 억제제로서 IC50가 3.3 nM이고 Ki가 각각 0.9 nM입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1454555-29-3
Sample solution is provided at 25 µL, 10mM.
LP-935509 is a small-molecule adapter protein-2 associated kinase 1 (AAK1) selective and brain-penetrantinhibitor (IC50=3.3 nM), a ATP-competitive inhibitor with a Ki of 0.9 nM. LP-935509 is a potent inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure[1].
[1]. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.
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