STC-15 |
| Catalog No.GC73680 |
STC-15 는 경구 활성 RNA 금속 전이효소 METTL3 억제제로서 항종양 면역을 활성화하고 종양의 미세 환경을 재창조하는 활성을 가지고 있다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2648257-56-9
Sample solution is provided at 25 µL, 10mM.
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STC-15 is an orally active RNA metltransferase METTL3 inhibitor with the activity of activating anti-tumor immunity and reshaping the tumor microenvironment. STC-15 inhibits tumor growth by activating anti-cancer immune responses associated with increased interferon signaling and synergizes with T-cell checkpoint blockade. STC-15 can be used in the study of proliferative diseases such as cancer and autoimmune diseases.
STC-15 (0.5 µM; 48 h) induces the expression of endogenous IFN signaling in the Caov3 ovarian cell line[3].
STC-15 (administered for 12 days) reduces tumor volume in mice with the MC38 colorectal syngeneic model compared to control mice[3].
References:
[1]. Wesley Peter Blackaby, et al. Polyheterocyclic compounds as mettl3 inhibitors. Patent WO2021111124A1. [2]. Ofir-Rosenfeld Y, et al. STC-15, an oral small molecule inhibitor of the RNA metltransferase METTL3, inhibits tumour growth through activation of anti-cancer immune responses associated with increased interferon signalling, and synergises with T cell checkpoint blockade[J]. European Journal of Cancer, 2022, 174: S123. [3]. Ofir-Rosenfeld Y, et al. STC-15, a small molecule inhibitor of the RNA metltransferase METTL3, activates anti-tumor immunity and reshapes the tumor microenvironment[C]//MOLECULAR CANCER THERAPEUTICS. 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA: AMER ASSOC CANCER RESEARCH, 2023, 22(12).
| Cas No. | 2648257-56-9 | SDF | |
| Formula | C24H25N5O2 | M.Wt | 415.49 |
| Solubility | DMSO : 116.67 mg/mL (280.80 mM; Need ultrasonic) | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.4068 mL | 12.034 mL | 24.068 mL |
| 5 mM | 0.4814 mL | 2.4068 mL | 4.8136 mL |
| 10 mM | 0.2407 mL | 1.2034 mL | 2.4068 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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