STh |
Catalog No.GC61489
One-Click Copy Product Info
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STh는 장독소 유발성 대장균 (ETEC)에 의해 생성되는 소형 열안정성 장독소이다. STh는 세 개의 이황화물 가교를 포함한 19개 아미노산 다펩타이드이다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 118447-40-8
Sample solution is provided at 25 µL, 10mM.
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STh는 장독소 유발성 대장균 (ETEC)에 의해 생성되는 소형 열안정성 장독소이다. STh는 세 개의 이황화물 가교를 포함한 19개 아미노산 다펩타이드이다. STh는 소장 상피세포 표면의 장 구아닐산 사이클라아제 C에 결합해서 세포내 cGMP 수준의 증가를 자극하고 장액 분비 증가와 전해질 불균형을 유발해서 분비성 설사를 일으킨다[3]. STh는 종종 백신 개발에 사용되지만 그 낮은 면역원성과 작은 크기는 도전 과제를 제시하고 면역 반응을 유도하기 위해 단백질이나 화학적 결합을 사용해야 한다[4].
References:
[1] Shimonishi Y, Hidaka Y, Koizumi M, et al. Mode of disulfide bond formation of a heat‐stable enterotoxin (STh) produced by a human strain of enterotoxigenic Escherichia coli[J]. FEBS letters, 1987, 215(1): 165-170.
[2] Dubreuil J D. Escherichia coli heat-stable enterotoxins[J]. The Comprehensive Sourcebook of Bacterial Protein Toxins; Elsevier: Amsterdam, The Netherlands, 2015: 874-910.
[3] Prasad H, Mathew J K K, Visweswariah S S. Receptor guanylyl cyclase C and cyclic GMP in health and disease: perspectives and therapeutic opportunities[J]. Frontiers in Endocrinology, 2022, 13: 911459.
[4] Wang H, Zhong Z, Luo Y, et al. Heat-stable enterotoxins of enterotoxigenic Escherichia coli and their impact on host immunity[J]. Toxins, 2019, 11(1): 24.
| Cas No. | 118447-40-8 | SDF | |
| Formula | C79H112N22O30S6 | M.Wt | 2042.25 |
| Solubility | Storage | Store at -20°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 489.7 μL | 2.4483 mL | 4.8966 mL |
| 5 mM | 97.9 μL | 489.7 μL | 979.3 μL |
| 10 mM | 49 μL | 244.8 μL | 489.7 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)