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surface antigen (208-215) [Hepatitis B Virus] (Synonyms: H2N-Ile-Leu-Ser-Pro-Phe-Leu-Pro-Leu-OH )

Catalog No.GP10068

Surface antigen used for signs of infection

Products are for research use only. Not for human use. We do not sell to patients.

surface antigen (208-215) [Hepatitis B Virus] Chemical Structure

Size 가격 재고 수량
1mg
US$35.00
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5mg
US$111.00
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10mg
US$193.00
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25mg
US$270.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

The nucleocapsid of hepatitis B virus is covered by an envelope of HBV surface antigen (HBsAg), which has the common, group-specific determinant a. The four major subtypes of HBsAg, adw, adr, ayw and ayr, are generated,? and they have been proposed to represent? the? phenotypic? expression? of the? four? major? genotypes? of HBV1. HBsAg subtypes show distinct geographical distributions2 and may provide historical information on the migration of ancestors carrying HBV of a particular subtype3.

The HBsAg, localized on the surface of the infectious Dane particle is considered to be the antigen responsible for conferring immunity to infection with hepatitis B4. A larger amount is found on filaments of 20-nm diameter and variable length. By far the most HBsAg is present on small, noninfectious, 20-nm particles5.

Refences:
1.Le Bouvier, G. L., Mccollum, R. W., Hierholzer, W. J., Irwin, G. R., Krugman, S. & Giles, J. P. (1972). Subtypes of Australia antigen and hepatitis-B virus.? Journal of the American Medical Association 222,? 928-930
2.Courouce-Pauty, A. M., Plancon, A. & Soulier, J. P.? (1983). Distribution of HBsAg subtypes in the world.? Vox? sanguinis 44,? 197-211.
3.Yamashita, Y., Kurashina, S., Miyakawa, Y. & Mayumi, M. (1975).? South-to-north gradient in distribution of the r determinant of hepatitis B surface antigen in Japan.? Journal of Infectious Diseases 131, 567-569.
4.A. M. Moriarty, B. H. Hoyer et al. Expression of the hepatitis B virus surface antigen gene in cell culture by using a simian virus 40 vector. Proc. Nati. Acad. Sci. 78: ?2606-2610(1981).

Chemical Properties

Cas No. SDF
Synonyms H2N-Ile-Leu-Ser-Pro-Phe-Leu-Pro-Leu-OH
Canonical SMILES NC(C(C)CC)C(NC(C(NC(CO)C(N1CCCC1C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C(N3CCCC3C(NC(C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)CC(C)C)=O
Formula C46H74N8O10 M.Wt 899.13
Solubility ≥89.9mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.1122 mL 5.5609 mL 11.1219 mL
5 mM 0.2224 mL 1.1122 mL 2.2244 mL
10 mM 0.1112 mL 0.5561 mL 1.1122 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

리뷰

Review for surface antigen (208-215) [Hepatitis B Virus]

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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