TPI-287, a blood-brain barrier-permeable microtubule stabilizer, can significantly reduce metastatic colonization of breast cancer in the brain.
TPI-287(i.v., 18 mg/kg, every 4 days, 41 days) can effectively reduce tumor volume and inhibit tumor growth in mouse tumor models inoculated with 231-BR breast cancer cells[1].
References:
[1]. Daniel P Fitzgerald, et al. TPI-287, a new taxane family member, reduces the brain metastatic colonization of breast cancer cells. Mol Cancer Ther. 2012 Sep;11(9):1959-67.