Cell Cycle/Checkpoint

Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.
Products for Cell Cycle/Checkpoint
- CAS 등록 번호 상품명 정보
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GC40702
α-D-Galactopyranosylphenyl isothiocyanate
α-D-Galactopyranosylphenyl isothiocyanate is a chemically activated form of galactose that has been used to prepare various neoglycoproteins, which consist of a glycosylated serum albumin substituted with either fluorescein or methotrexate.
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GC41676
(±)-Nornicotine
(±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist.
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GC49482
(±)-Nornicotine-d4
An internal standard for the quantification of (±)-nornicotine
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GC41684
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane (BMC) is a cyclohexane with two mercaptoacetamido groups.
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GC40802
(±)12(13)-DiHOME
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.
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GC41656
(±)2-(14,15-Epoxyeicosatrienoyl) Glycerol
2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system.
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GC45890
(+)-Abscisic Acid-d6
(+)-Abscisic Acid-d6(ABA-d6)은 Abscisic acid로 표지된 중수소입니다.
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GC62728
(1E)-CFI-400437 dihydrochloride
(1E)-CFI-400437 이염산염은 강력한 PLK4(IC50=0.6nM) 억제제이며 PLK 계열의 다른 구성원(>10μM)에 대해 선택적입니다. (1E)-CFI-400437 이염산염은 각각 0.37, 0.21, 0.48 및 0.18μM의 IC50으로 Aurora A, Aurora B, KDR 및 FLT-3을 억제합니다. 항증식 활동.
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GC49690
(3R,5R)-Rosuvastatin (calcium salt)
A potential impurity found in bulk preparations of rosuvastatin
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GC41268
(E)-2-Hexadecenal
Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase.
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GC41701
(E)-2-Hexadecenal Alkyne
(E)-2-Hexadecenal alkyne is an alkyne version of the sphingolipid degradation product (E)-2-hexadecenal that can be used as a click chemistry probe.
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GC46335
(E)-Fenpyroximate
(E)-Fenpyroximate는 강력한 살비제입니다.
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GC10419
(R)-CCG-1423
Rho inhibitor
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GC16429
(R)-DRF053 dihydrochloride
cdk/CK1 inhibitor,potent and ATP-competitive
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GC41719
(R)-nitro-Blebbistatin
(R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin, which is the inactive form of (-)-blebbistatin.
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GC46347
(S)-(+)-Methoprene
(S)-메토프렌은 유충 호르몬 유사체로 곤충이 번데기에서 성충으로 변하는 것을 막고 살충제로 사용됩니다.
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GC41557
(S)-3'-amino Blebbistatin
(S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.
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GC41484
(S)-3'-hydroxy Blebbistatin
(S)-3'-hydroxy Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.
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GC52192
(S)-4'-nitro-Blebbistatin
(S)-4'-nitro-Blebbistatin은 생리학적, 발달 및 세포 생물학 연구에서 미오신 II의 특정 역할에 대한 연구에 사용되는 비세포독성, 광안정성, 형광성 및 특정 미오신 II 억제제입니다.
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GC14497
(S)-CCG-1423
Rho inhibitor
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GC34999
(S)-Ceralasertib
(S)-Ceralasertib((S)-AZD6738)은 특허 WO2011154737A1, 화합물 II에서 추출되며 2.578 nM의 IC50을 나타냅니다.(S)-Ceralasertib은 우수한 전임상 및 PK를 가진 강력하고 선택적인 설폭시민 모르폴리노피리미딘 ATR 억제제입니다. ) 특성.(S)-Ceralasertib은 수용성을 개선하고 CYP3A4 시간 의존적 억제를 제거하기 위해 개발되었습니다.
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GC46351
(S)-CR8
(S)-CR8은 CR8의 S-이성질체이다. (S)-CR8은 CDK2/사이클린 E, CDK2/사이클린 A, CDK9/사이클린 T, CDK5/p25 및 CDK1/사이클린에 대해 IC50이 0.060, 0.080, 0.11, 0.12 및 0.15μM인 강력하고 선택적인 CDK 억제제입니다. B, 각각. (S)-CR8은 SH-SY5Y 세포 생존을 감소시킵니다(IC50 0.40μM).
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GC41737
(S)-Glycyl-H-1152 (hydrochloride)
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability.
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GC40145
(S)-Laudanosine
(S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium.
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GC41739
(S)-nitro-Blebbistatin
(S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.
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GC18275
1,2-Dihexadecyl-sn-glycero-3-PC
1,2-Dihexadecyl-sn-glycero-3-PC is a synthetic ether-linked phospholipid containing hexadecyl groups at the sn-1 and sn-2 positions.
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GC45783
1,2-Dioleoyl-rac-glycerol-13C3
An internal standard for the quantification of 1,2-dioleoyl-rac-glycerol
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GC46379
1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)
1,2-Dioleoyl-sn-glycero-3-PS(나트륨염)는 포스포세린/포스파티딜세린을 대체합니다.
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GC41823
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid.
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GC46385
1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-α-D-Mannopyranose
A ManNAc analog and building block
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GC19528
1,4-Benzoquinone
A toxic metabolite of benzene
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GC18726
1-Methyl-1,4-dihydronicotinamide
1-메틸-1,4-디히드로니코틴아미드는 니코틴아미드의 유도체입니다.
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GC49736
10-acetyl Docetaxel
10-아세틸 도세탁셀(10-Acetyl docetaxel)은 항암 활성이 있는 도세탁셀의 유사체입니다. 도세탁셀은 유사분열 억제 활성이 있는 미세소관 분해 억제제입니다.
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GC12954
10-DAB (10-Deacetylbaccatin)
An inhibitor of microtubule assembly
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GC35044
10-Deacetyl-7-xylosyl paclitaxel
10-Deacetyl-7-xylosyl paclitaxel은 개선된 약리학적 특징을 가진 Paclitaxel(미세관 안정화제, tubulin 중합 강화) 유도체입니다.
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GC35045
10-Oxo Docetaxel
10-Oxo Docetaxel(Docetaxel Impurity 1)은 놀라운 항종양 특성과 Docetaxel 중간체를 갖는 새로운 분류군입니다.
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GC17295
10058-F4
10058-F4는 c-Myc 표적 유전자 발현의 c-Myc-Max 이량체화 및 전이활성화를 방지하는 c-Myc 억제제입니다.
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GC63576
10074-A4
10074-A4는 c-Myc 억제제입니다. 10074-A4는 펩타이드 사슬을 따라 다른 위치에서 c-Myc370-409에 결합할 수 있습니다. 10074-A4는 항암 효과가 있습니다.
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GC14918
10074-G5
10074-G5는 IC50이 146μM인 c-Myc-Max 이량체화 억제제입니다.
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GC40448
12(S)-HETE
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.
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GC46434
13C15-Nivalenol
An internal standard for the quantification of nivalenol
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GC49390
13C6-4-Nitroaniline
An internal standard for the quantification of 4-nitroaniline
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GC41110
16-epi Latrunculin B
16-epi Latrunculin B, first isolated from the Red Sea sponge N.
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GC48423
19-O-Acetylchaetoglobosin A
19-O-Acetylchaetoglobosin A는 cytochalasan alkaloid로 C. globosum에서 원래 분리된 곰팡이 대사산물로 액틴 중합 억제 및 세포 독성 활성을 가지고 있습니다. 19-O-아세틸키토글로보신 A는 HeLa 자궁경부암 세포에 세포독성을 나타냅니다.
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GC42151
2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis.
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GC40947
2,3-Dimethoxy-5-methyl-p-benzoquinone
2,3-Dimethoxy-5-methyl-p-benzoquinone(CoQO)은 강력한 경구 활성 유비퀴논 화합물로 Antrodia cinnamomea에서 추출할 수 있습니다.
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GC49671
2,3-Oxidosqualene
An intermediate in the biosynthesis of sterols
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GC45324
2,5-dimethyl Celecoxib
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GC49362
2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline
A food-derived carcinogen
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GC52029
2-Aminoflubendazole
2-아미노플루벤다졸은 벤지미다졸의 대사산물입니다.
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GC40675
2-deoxy-Artemisinin
2-deoxy-Artemisinin is an inactive metabolite of the antimalarial agent artemisinin.
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GC15084
2-Methoxyestradiol (2-MeOE2)
A natural metabolite of estradiol
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GC52140
2-Methoxyhydroquinone
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GC42161
2H-Cho-Arg (trifluoroacetate salt)
2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.
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GC40618
3',4',7-Trihydroxyisoflavone
3',4',7-Trihydroxyisoflavone, Daidzein의 주요 대사 산물은 Cot(Tpl2/MAP3K8) 및 MKK4의 ATP 경쟁적 억제제입니다. 3',4',7-트리하이드록시이소플라본은 항암, 항혈관신생, 화학보호 및 자유 라디칼 소거 활성이 있습니다.
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GC45332
3'-Dephosphocoenzyme A
An intermediate in the biosynthesis of CoA
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GC42239
3,6-diacetoxy Phthalonitrile
3,6-디아세톡시 프탈로니트릴은 세포 투과성 형광 프로브입니다.
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GC12314
3-(4-Pyridyl)indole
3-(4-피리딜)인돌(Rockout)은 25μM의 IC50을 갖는 Rho-kinase(ROCK) 억제제입니다.
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GC46582
3-Acetyldeoxy Nivalenol-13C17
An internal standard for the quantification of 3-acetyldeoxy nivalenol
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GC52129
3-Amino-5-hydroxybenzoic Acid
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GC15389
360A
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GC10115
360A iodide
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GC14186
3MB-PP1
부피가 큰 퓨린 유사체인 3MB-PP1은 Polo-like kinase 1(Plk1) 억제제입니다.
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GC45354
4β-Hydroxywithanolide E
4β, Physalis peruviana L.에서 분리된 하이드록시위타놀라이드 E.
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GC17271
4'-Demethylepipodophyllotoxin
An inhibitor of tubulin polymerization
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GC46606
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline
A heterocyclic building block
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GC46635
4-deoxy Nivalenol-13C15
An internal standard for the quantification of 4-deoxy nivalenol
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GC18359
4-Epianhydrochlortetracycline (hydrochloride)
4-Epianhydrochlortetracycline is a derivative of tetracycline .
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GC42449
4-Methylumbelliferyl-α-L-Iduronide (free acid)
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate.
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GC49244
4-oxo Isotretinoin
An active metabolite of isotretinoin
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GC52365
4-tert-Octylphenol monoethoxylate
An alkylphenolethoxylate and a degradation product of non-ionic surfactants
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GC52227
5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone
An active metabolite of various polyphenols
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GC46681
5-Bromouridine
A brominated uridine analog
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GC45357
5-Chlorouracil
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GC41156
5-Octyl D-glutamate
5-Octyl D-glutamate, also known as 5-octyl ester D-glutamate, is a stable, cell-permeable molecule that generates free D-glutamate upon hydrolysis of the ester bond by cytoplasmic esterases.
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GC41423
5-trans Prostaglandin E2
5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1.
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GC42586
6α-hydroxy Paclitaxel
6α-하이드록시 파클리탁셀은 파클리탁셀의 1차 대사산물입니다. 6α-하이드록시 파클리탁셀은 파클리탁셀과 유사한 억제 효능으로 유기 음이온 수송 폴리펩타이드 1B1/SLCO1B1(OATP1B1)에 대한 시간 의존적 효과를 유지하지만, 더 이상 OATP1B3의 시간 의존적 억제를 나타내지 않습니다. 6α-hydroxy Paclitaxel은 암 연구에 사용할 수 있습니다.
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GC45969
6β-hydroxy Eplerenone
A major metabolite of eplerenone
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GC46721
6-Chloro-2-fluoropurine
A heterocyclic building block
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GC48721
6-O-Demethyl Griseofulvin
A metabolite of griseofulvin
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GC15478
6H05
6H05는 발암성 돌연변이 K-Ras(G12C)의 선택적 알로스테릭 억제제입니다.
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GC40202
7α-hydroxy Cholesterol-d7
7α-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy cholesterol by GC- or LC-MS.
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GC46733
7,12-Dimethylbenz[a]anthracene
7,12-Dimethylbenz[a]anthracene은 다환 방향족 탄화수소(PAH)로서 발암 활성이 있습니다. 7,12-디메틸벤즈[a]안트라센은 다양한 설치류 모델에서 종양 형성을 유도하는 데 사용됩니다.
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GC35188
7-Epi-10-oxo-docetaxel
7-Epi-10-oxo-docetaxel(Docetaxel Impurity 2)은 고성능 액체 크로마토그래피(HPLC)에 의해 검출된 도세탁셀의 불순물이다.
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GC35189
7-Epi-docetaxel
7-에피-10-옥소-도세탁셀(도세탁셀 불순물 C; 7-에피탁소테레)은 도세탁셀의 불순물이다.
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GN10625
7-Epitaxol
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GC42610
7-hydroxy Pestalotin
7-하이드록시 페스탈로틴(LL-P880β)은 곰팡이 대사산물입니다.
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GC42616
7-oxo Staurosporine
7-oxo Staurosporine is an antibiotic originally isolated from S.
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GC35197
7-xylosyltaxol
7-xylosyltaxol(Taxol-7-xyloside)은 탁솔(Paclitaxel) 유도체이고; Paclitaxel은 tubulin에 결합하고 microtubules의 분해를 억제합니다.
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GC52126
8-chloro Caffeine
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GC40844
9-(2,2-Dicyanovinyl)julolidine
9-(2,2-Dicyanovinyl)julolidine(9-(2,2-Dicyanovinyl)julolidine)은 분자 회전자이자 독특한 형광 염료로 tubulin과 actin에 결합하여 중합 시 형광 강도를 급격히 증가시킵니다.
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GC48986
9-hydroxy Stearic Acid
A hydroxy fatty acid
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GC42665
AAF-CMK (trifluoroacetate salt)
Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides.
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GC35216
AAPK-25
AAPK-25는 항종양 활성이 있는 강력하고 선택적인 Aurora/PLK 이중 억제제로, 생체지표 히스톤 H3Ser10 인산화에 따라 세포자멸사 급증이 뒤따르는 전중기 단계에서 유사분열 지연 및 세포 정지를 유발할 수 있습니다. AAPK-25는 Kd 값이 23-289nM인 Aurora-A, -B 및 -C와 Kd 값이 55-456nM인 PLK-1, -2 및 -3을 대상으로 합니다.
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GC25025
Abraxane
Abraxane (Nab-Paclitaxel), a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system.
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GC15875
ABT-751 (E7010)
ABT-751(E7010)(E 7010)은 신경모세포종 및 비신경모세포종 세포주에서 IC50이 각각 약 1.5 및 3.4 μM인 새로운 생체이용 가능한 튜불린 결합 및 유사분열 방지 설폰아미드 제제입니다.
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GC42683
Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp
Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human neutrophil elastase (kcat/Km = 531 mM-1s-1).
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GC52499
Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt)
A sensitive substrate for neutrophil elastase
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GC42684
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt)
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1).
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GA20494
Ac-Asp-Glu-Val-Asp-pNA
The cleavage of the chromogenic caspase-3 substrate Ac-DEVD-pNA can be monitored at 405 nm.