Cell Cycle/Checkpoint
Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.
Targets for Cell Cycle/Checkpoint
- ATM/ATR(24)
- Aurora Kinase(22)
- Cdc42(4)
- Cdc7(3)
- Chk(14)
- c-Myc(27)
- CRM1(8)
- Cyclin-Dependent Kinases(77)
- E1 enzyme(1)
- G-quadruplex(12)
- Haspin(6)
- HMTase(1)
- Kinesin(27)
- Ksp(4)
- Microtubule/Tubulin(254)
- Mps1(15)
- Mitotic(7)
- RAD51(16)
- ROCK(71)
- Rho(13)
- PERK(11)
- PLK(41)
- PTEN(6)
- Wee1(9)
- PAK(25)
- Arp2/3 Complex(8)
- Dynamin(14)
- ECM & Adhesion Molecules(54)
- Cholesterol Metabolism(12)
- Endomembrane System & Vesicular Trafficking(36)
- G1(51)
- G2/M(40)
- G2/S(17)
- Genotoxic Stress(23)
- Inositol Phosphates(65)
- Proteolysis(183)
- Cytoskeleton & Motor Proteins(65)
- Cellular Chaperones(14)
- Cyclin G-associated Kinase (GAK)(1)
- MARK(3)
- NEKs(1)
Products for Cell Cycle/Checkpoint
- Cat.No. 상품명 정보
-
GC40702
α-D-Galactopyranosylphenyl isothiocyanate
α-D-Galactopyranosylphenyl isothiocyanate is a chemically activated form of galactose that has been used to prepare various neoglycoproteins, which consist of a glycosylated serum albumin substituted with either fluorescein or methotrexate.
-
GC45226
β-BHC
β-HCH, β-Hexachlorocyclohexane, β-Lindane
β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane. -
GC41676
(±)-Nornicotine
DL-Nornicotine, (R,S)-Nornicotine
(±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. -
GC49482
(±)-Nornicotine-d4
DL-Nornicotine-d4, (R,S)-Nornicotine-d4
An internal standard for the quantification of (±)-nornicotine - GC46308 (±)-Sitagliptin-d4 (hydrochloride) A neuropeptide with diverse biological activities
-
GC41684
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane
BMC, Vectrase P
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane (BMC) is a cyclohexane with two mercaptoacetamido groups. -
GC40802
(±)12(13)-DiHOME
Isoleukotoxin diol
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.
-
GC41656
(±)2-(14,15-Epoxyeicosatrienoyl) Glycerol
(±)214,15EG
2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system. -
GC45890
(+)-Abscisic Acid-d6
(S)-(+)-Abscisic acid-d6; ABA-d6
(+)-Abscisic Acid-d6(ABA-d6)은 Abscisic acid로 표지된 중수소입니다. - GC70332 (+)-Erinacin A (+)-Erinacin A 는 버섯 원숭이머리버섯에서 분리 될 수있는 항암 화합물입니다.
- GC62728 (1E)-CFI-400437 dihydrochloride (1E)-CFI-400437 이염산염은 강력한 PLK4(IC50=0.6nM) 억제제이며 PLK 계열의 다른 구성원(>10μM)에 대해 선택적입니다. (1E)-CFI-400437 이염산염은 각각 0.37, 0.21, 0.48 및 0.18μM의 IC50으로 Aurora A, Aurora B, KDR 및 FLT-3을 억제합니다. 항증식 활동.
- GC49690 (3R,5R)-Rosuvastatin (calcium salt) A potential impurity found in bulk preparations of rosuvastatin
-
GC41698
(D)2-Rh 110 (trifluoroacetate salt)
D2R, (Asp)2-Rhodamine 110, Rhodamine 110 bis-(L-aspartic acid amide)
(D)2-Rh 110 is a fluorogenic caspase substrate. -
GC41268
(E)-2-Hexadecenal
trans-2-Hexadecenal
Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase. - GC41701 (E)-2-Hexadecenal Alkyne (E)-2-Hexadecenal alkyne is an alkyne version of the sphingolipid degradation product (E)-2-hexadecenal that can be used as a click chemistry probe.
-
GC46335
(E)-Fenpyroximate
Fenpyroximate, NNI-850
(E)-Fenpyroximate는 강력한 살비제입니다. - GC10419 (R)-CCG-1423 Rho inhibitor
- GC16429 (R)-DRF053 dihydrochloride cdk/CK1 inhibitor,potent and ATP-competitive
- GC72915 (R)-MRT199665 (R)-MRT199665는 MRT199665의 이기체입니다.
-
GC41719
(R)-nitro-Blebbistatin
R(-)7Desmethyl8nitro Blebbistatin
(R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin, which is the inactive form of (-)-blebbistatin. -
GC46347
(S)-(+)-Methoprene
Altosid, d-Methoprene, ZR 2458
(S)-메토프렌은 유충 호르몬 유사체로 곤충이 번데기에서 성충으로 변하는 것을 막고 살충제로 사용됩니다. -
GC41557
(S)-3'-amino Blebbistatin
(-)-3'-amino Blebbistatin, m-amino Blebbistatin, meta-amino Blebbistatin
(S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. -
GC41484
(S)-3'-hydroxy Blebbistatin
(-)-3'-hydroxy Blebbistatin, meta-hydroxy-Blebbistatin, m-hydroxy-Blebbistatin
(S)-3'-hydroxy Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. -
GC52192
(S)-4'-nitro-Blebbistatin
(-)-4'-nitro-Blebbistatin, p-nitro-Blebbistatin, para-nitro-Blebbistatin
(S)-4'-nitro-Blebbistatin은 생리학적, 발달 및 세포 생물학 연구에서 미오신 II의 특정 역할에 대한 연구에 사용되는 비세포독성, 광안정성, 형광성 및 특정 미오신 II 억제제입니다. - GC14497 (S)-CCG-1423 Rho inhibitor
-
GC34999
(S)-Ceralasertib
(S)-AZD6738
(S)-Ceralasertib((S)-AZD6738)은 특허 WO2011154737A1, 화합물 II에서 추출되며 2.578 nM의 IC50을 나타냅니다.(S)-Ceralasertib은 우수한 전임상 및 PK를 가진 강력하고 선택적인 설폭시민 모르폴리노피리미딘 ATR 억제제입니다. ) 특성.(S)-Ceralasertib은 수용성을 개선하고 CYP3A4 시간 의존적 억제를 제거하기 위해 개발되었습니다. - GC46351 (S)-CR8 (S)-CR8은 CR8의 S-이성질체이다. (S)-CR8은 CDK2/사이클린 E, CDK2/사이클린 A, CDK9/사이클린 T, CDK5/p25 및 CDK1/사이클린에 대해 IC50이 0.060, 0.080, 0.11, 0.12 및 0.15μM인 강력하고 선택적인 CDK 억제제입니다. B, 각각. (S)-CR8은 SH-SY5Y 세포 생존을 감소시킵니다(IC50 0.40μM).
-
GC41737
(S)-Glycyl-H-1152 (hydrochloride)
Rho Kinase Inhibitor IV
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. -
GC40145
(S)-Laudanosine
(+)-Laudanosine, L-Laudanosine, L-(+)-Laudanosine, NSC 35045
(S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium. -
GC41739
(S)-nitro-Blebbistatin
S(-)7Desmethyl8nitro Blebbistatin
(S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. -
GC40121
(Z-DEVD)2-Rh 110 (trifluoroacetate salt)
(Z-Asp-Glu-Val-Asp)2-Rhodamine 110
(Z-DEVD)2-Rh 110 is a fluorogenic substrate for caspase-3. -
GC41742
(Z-IETD)2-Rh 110 (trifluoroacetate salt)
(Z-Ile-Glu-Thr-Asp)2-R110, Rhodamine 110 bis-(N-CBZ-IETD)2
(Z-IETD)2-Rh 110 is a fluorogenic substrate for caspase-8. -
GC18275
1,2-Dihexadecyl-sn-glycero-3-PC
1,2-Dihexadecyl-sn-glycero-3-Phosphocholine
1,2-Dihexadecyl-sn-glycero-3-PC is a synthetic ether-linked phospholipid containing hexadecyl groups at the sn-1 and sn-2 positions. - GC45783 1,2-Dioleoyl-rac-glycerol-13C3 An internal standard for the quantification of 1,2-dioleoyl-rac-glycerol
-
GC46379
1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)
1,2-DOPS, 18:1/18:1-PS; PS(18:1/18:1), 1,2-Dioctadecenoyl-sn-glycero-3-Phosphoserine, 1,2-Dioctadecenoyl-sn-glycero-3-Phosphatidylserine
1,2-Dioleoyl-sn-glycero-3-PS(나트륨염)는 포스포세린/포스파티딜세린을 대체합니다. -
GC41823
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)
biotin-cap-DPPE
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid.
- GC46385 1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-α-D-Mannopyranose A ManNAc analog and building block
-
GC19528
1,4-Benzoquinone
p-Benzoquinone, NSC 36324, p-Quinone
A toxic metabolite of benzene - GC18726 1-Methyl-1,4-dihydronicotinamide 1-메틸-1,4-디히드로니코틴아미드는 니코틴아미드의 유도체입니다.
-
GC90829
1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-PC
인지질-포르피린 결합체
-
GC49736
10-acetyl Docetaxel
PNU 101383, 10-acetyl Taxotere
10-아세틸 도세탁셀(10-Acetyl docetaxel)은 항암 활성이 있는 도세탁셀의 유사체입니다. 도세탁셀은 유사분열 억제 활성이 있는 미세소관 분해 억제제입니다. -
GC12954
10-DAB (10-Deacetylbaccatin)
NSC 251677
An inhibitor of microtubule assembly - GC35044 10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyl paclitaxel은 개선된 약리학적 특징을 가진 Paclitaxel(미세관 안정화제, tubulin 중합 강화) 유도체입니다.
- GC35045 10-Oxo Docetaxel 10-Oxo Docetaxel(Docetaxel Impurity 1)은 놀라운 항종양 특성과 Docetaxel 중간체를 갖는 새로운 분류군입니다.
- GC17295 10058-F4 10058-F4는 c-Myc-Max 이량체 형성을 억제하고 c-Myc 대상 유전자 발현의 전사 활성을 방지하는 c-Myc 저해제이다.
- GC63576 10074-A4 10074-A4는 c-Myc 억제제입니다. 10074-A4는 펩타이드 사슬을 따라 다른 위치에서 c-Myc370-409에 결합할 수 있습니다. 10074-A4는 항암 효과가 있습니다.
- GC14918 10074-G5 10074-G5는 IC50이 146μM인 c-Myc-Max 이량체화 억제제입니다.
-
GC40448
12(S)-HETE
12(S)-Hydroxyeicosatetraenoic Acid
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.
- GC40449 12(S)-HETE MaxSpec® Standard 12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.
-
GC26213
13,14-Dihydro-13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine-14-carbonitrile
DIHYDROSANGUINARINE
- GC46434 13C15-Nivalenol An internal standard for the quantification of nivalenol
-
GC49390
13C6-4-Nitroaniline
13C6-p-Nitroaniline
An internal standard for the quantification of 4-nitroaniline - GC40452 15(S)-HETE MaxSpec® Standard 15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway.
-
GC46446
15-deoxy-δ12,14-Prostaglandin J2-biotin
15deoxyΔ12,14PGJ2biotin
A neuropeptide with diverse biological activities - GC41110 16-epi Latrunculin B 16-epi Latrunculin B, first isolated from the Red Sea sponge N.
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GC48423
19-O-Acetylchaetoglobosin A
Chaetoglobosin A Acetate
19-O-Acetylchaetoglobosin A는 cytochalasan alkaloid로 C. globosum에서 원래 분리된 곰팡이 대사산물로 액틴 중합 억제 및 세포 독성 활성을 가지고 있습니다. 19-O-아세틸키토글로보신 A는 HeLa 자궁경부암 세포에 세포독성을 나타냅니다. -
GC42151
2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
dGMP
2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. -
GC90819
2,3,7,8-Tetrachlorodibenzofuran
다이옥신과 다이벤조퓨란의 폴리클로린화물
-
GC40947
2,3-Dimethoxy-5-methyl-p-benzoquinone
Coenzyme Q0, CoQ0
2,3-Dimethoxy-5-methyl-p-benzoquinone(CoQO)은 강력한 경구 활성 유비퀴논 화합물로 Antrodia cinnamomea에서 추출할 수 있습니다. -
GC49671
2,3-Oxidosqualene
(3R,S)-Oxidosqualene, Squalene 2,3-oxide
An intermediate in the biosynthesis of sterols -
GC45324
2,5-dimethyl Celecoxib
DMC
-
GC49362
2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline
MeIQx
A food-derived carcinogen -
GC52029
2-Aminoflubendazole
Hydrolyzed Flubendazole
2-아미노플루벤다졸은 벤지미다졸의 대사산물입니다. -
GC90840
2-Chloroadenosine-5'-O-diphosphate (sodium salt)
ADP의 유도체
- GC40675 2-deoxy-Artemisinin 2-deoxy-Artemisinin is an inactive metabolite of the antimalarial agent artemisinin.
- GC62777 2-Methoxy-4-vinylphenol 천연 발아 억제제인 2-메톡시-4-비닐페놀(2M4VP)은 강력한 항염 효과를 발휘합니다.
-
GC15084
2-Methoxyestradiol (2-MeOE2)
2Hydroxyestradiol 2methyl ether, 2ME2, NSC 659853, Panzem
2-Methoxyestradiol (2-MeOE2)은 HIF-1α 억제제이다. -
GC52140
2-Methoxyhydroquinone
o-Methoxyhydroquinone, MHQ, MOHQ
-
GC91133
2-n-Dodecylfuran
인공 중간체
- GC48449 28-(Poc-amino)betulin
- GC42161 2H-Cho-Arg (trifluoroacetate salt) 2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.
-
GC62033
3α-Hydroxy pravastatin sodium
3α-Isopravastatin, R-416
3α-하이드록시 프라바스타틴 나트륨은 프라바스타틴의 주요 대사 산물입니다. -
GC40618
3',4',7-Trihydroxyisoflavone
3'-hydroxy Daidzein, 3’,4’,7-THIF
3',4',7-Trihydroxyisoflavone, Daidzein의 주요 대사 산물은 Cot(Tpl2/MAP3K8) 및 MKK4의 ATP 경쟁적 억제제입니다. 3',4',7-트리하이드록시이소플라본은 항암, 항혈관신생, 화학보호 및 자유 라디칼 소거 활성이 있습니다. -
GC45332
3'-Dephosphocoenzyme A
depCoA, Dephospho-CoA
An intermediate in the biosynthesis of CoA -
GC18452
3,4-Dichloroisocoumarin
3,4-DCI
A serine protease inhibitor -
GC42239
3,6-diacetoxy Phthalonitrile
ADB, 1,4-Diacetoxy-2,3-dicyanobenzene, 2,3-Dicyano-1,4-hydroquinone diacetate
3,6-디아세톡시 프탈로니트릴은 세포 투과성 형광 프로브입니다. -
GC12314
3-(4-Pyridyl)indole
Rho Kinase Inhibitor III,ROCK Inhibitor III,Rockout
3-(4-피리딜)인돌(Rockout)은 25μM의 IC50을 갖는 Rho-kinase(ROCK) 억제제입니다. -
GC46582
3-Acetyldeoxy Nivalenol-13C17
3-AcDON-13C17, DON 3-acetate-13C17, Deoxy Nivalenol-3-acetate-13C17
An internal standard for the quantification of 3-acetyldeoxy nivalenol -
GC52129
3-Amino-5-hydroxybenzoic Acid
AHBA
- GC15389 360A
- GC10115 360A iodide
- GC14186 3MB-PP1 부피가 큰 퓨린 유사체인 3MB-PP1은 Polo-like kinase 1(Plk1) 억제제입니다.
-
GC45354
4β-Hydroxywithanolide E
NSC 212509
4β, Physalis peruviana L.에서 분리된 하이드록시위타놀라이드 E. -
GC17271
4'-Demethylepipodophyllotoxin
(-)-4′-Demethylepipodophyllotoxin
An inhibitor of tubulin polymerization -
GC46606
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline
4-Aminophenylboronic Acid pinacol ester
A heterocyclic building block -
GC46635
4-deoxy Nivalenol-13C15
Vomitoxin-13C15, Deoxynivalenol-13C15, DON-13C15
An internal standard for the quantification of 4-deoxy nivalenol - GC18359 4-Epianhydrochlortetracycline (hydrochloride) 4-Epianhydrochlortetracycline is a derivative of tetracycline .
-
GC42449
4-Methylumbelliferyl-α-L-Iduronide (free acid)
4-Methylumbelliferyl-α-L-Idopyranosiduronic Acid, 4-MU-α-IdoA, MU-α-IdoA
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. -
GC49244
4-oxo Isotretinoin
Ro 22-6595
An active metabolite of isotretinoin -
GC52365
4-tert-Octylphenol monoethoxylate
NSC 5259, OP1EO
An alkylphenolethoxylate and a degradation product of non-ionic surfactants -
GC46687
5'-Deoxy-5'-methylthioadenosine-d3
5'-S-Methylthioadenosine-d3, MTA-d3, Vitamin L2-d3
A neuropeptide with diverse biological activities -
GC52227
5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone
(±)-δ-(3,4-Dihydroxyphenyl)-γ-Valerolactone, 5-(3',4'-Dihydroxyphenyl)-γ-VL
An active metabolite of various polyphenols -
GC73301
5-Aminosalicylic acid-d3
Mesalamine-d3; 5-ASA-d3; Mesalazine-d3
5-Aminosalicylic acid-d3 는 듀테륨 표시 5 - 아미노살리실산입니다. -
GC46681
5-Bromouridine
(–)-5-Bromouridine, BrU, BrUrd, NSC 38296
A brominated uridine analog - GC45357 5-Chlorouracil
- GC42548 5-hydroxy Saxagliptin (hydrochloride) 5-hydroxy Saxagliptin is a major active metabolite of saxagliptin.
-
GC41156
5-Octyl D-glutamate
5-Octyl ester D-glutamatic acid
5-Octyl D-glutamate, also known as 5-octyl ester D-glutamate, is a stable, cell-permeable molecule that generates free D-glutamate upon hydrolysis of the ester bond by cytoplasmic esterases. -
GC41423
5-trans Prostaglandin E2
transDinoprostone, 5,6trans PGE2
5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1. -
GC42586
6α-hydroxy Paclitaxel
6α-hydroxy Taxol
6α-하이드록시 파클리탁셀은 파클리탁셀의 1차 대사산물입니다. 6α-하이드록시 파클리탁셀은 파클리탁셀과 유사한 억제 효능으로 유기 음이온 수송 폴리펩타이드 1B1/SLCO1B1(OATP1B1)에 대한 시간 의존적 효과를 유지하지만, 더 이상 OATP1B3의 시간 의존적 억제를 나타내지 않습니다. 6α-hydroxy Paclitaxel은 암 연구에 사용할 수 있습니다. - GC63958 6α-Hydroxy Paclitaxel-d5 6α-Hydroxy Paclitaxel-d5는 6α로 표시된 중수소입니다. 6⛙-Hydroxy paclitaxel은 Paclitaxel의 주요 대사 산물입니다. 6α - 하이드록시 파클리탁셀은 파클리탁셀과 유사한 억제 효능으로 유기 음이온 수송 폴리펩타이드 1B1/SLCO1B1(OATP1B1)에 대한 시간 의존적 효과를 유지하지만, 더 이상 OATP1B3의 시간 의존적 억제를 나타내지 않습니다. 6⛙-Hydroxy paclitaxel은 암 연구에 사용할 수 있습니다.