WYneN is a chemoselective probe for the detection of sulfenylated proteins in live cells.1 It is selective for sulfenylated proteins over 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB) and 4,4′-dipyridyl disulfide (4-DPS). WYneN binds to sulfenylated proteins in live cells and can then be conjugated to azide-containing fluorescent probes for detection.
References:
[1]. Shi, Y., Fu, L., Yang, J., et al.Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targetingNat. Chem.13(11)1140-1150(2021).