Lipid N2-3L |
Catalog No.GC92067
One-Click Copy Product Info
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Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) that has been used in the generation of supramolecular lipid nanoparticles (SMLNPs) encapsulating mRNA for use in vitro and in vivo.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2924606-55-1
Sample solution is provided at 25 µL, 10mM.
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Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) that has been used in the generation of supramolecular lipid nanoparticles (SMLNPs) encapsulating mRNA for use in vitro and in vivo.1 SMLNPs containing lipid N2-3L and encapsulating a luciferase reporter accumulate at the site of injection and in the draining lymph nodes of mice. Lipid N2-3L-containing SMLNPs encapsulating ovalbumin mRNA and the toll-like receptor 7/8 (TLR7/8) agonist R-848 as an adjuvant promote dendritic cell maturation and antigen presentation, reduce tumor volume, and increase survival in an MC-38-OVA murine model of colon cancer.
References:
[1]. Qi, S., Zhang, X., Yu, X., et al.Supramolecular lipid nanoparticles based on host-guest recognition: A new generation delivery system of mrna vaccines for cancer immunotherapyAdv. Mater.36(23)e2311574(2024).
| Cas No. | 2924606-55-1 | SDF | |
| Chemical Name | 9Z-octadecenoic acid, 3-[2-[(2-hexyl-1-oxodecyl)oxy]ethyl]-14-hydroxy-12-(2-hydroxyethyl)-7-oxo-6-oxa-3,8,12-triazatetradec-1-yl ester | ||
| Canonical SMILES | O=C(CCCCCCC/C=C\CCCCCCCC)OCCN(CCOC(NCCCN(CCO)CCO)=O)CCOC(C(CCCCCCCC)CCCCCC)=O | ||
| Formula | C48H93N3O8 | M.Wt | 840.3 |
| Solubility | DMSO: Soluble: ≥10 mg/ml,Ethanol: Soluble: ≥10 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.1901 mL | 5.9503 mL | 11.9005 mL |
| 5 mM | 238 μL | 1.1901 mL | 2.3801 mL |
| 10 mM | 119 μL | 595 μL | 1.1901 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solution in methyl acetate
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)