GLPBio

Lipid N2-3L

Catalog No.: GC92067Purity:>95.00%
COASDSData Sheet
Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) that has been used in the generation of supramolecular lipid nanoparticles (SMLNPs) encapsulating mRNA for use in vitro and in vivo.

Products are for research use only. Not for human use. We do not sell to patients.

Lipid N2-3L
Cas No.: 2924606-55-1
1 mgIn Stock
$105.00
1
5 mgIn Stock
$394.00
1
10 mgIn Stock
$578.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) that has been used in the generation of supramolecular lipid nanoparticles (SMLNPs) encapsulating mRNA for use in vitro and in vivo.1 SMLNPs containing lipid N2-3L and encapsulating a luciferase reporter accumulate at the site of injection and in the draining lymph nodes of mice. Lipid N2-3L-containing SMLNPs encapsulating ovalbumin mRNA and the toll-like receptor 7/8 (TLR7/8) agonist R-848 as an adjuvant promote dendritic cell maturation and antigen presentation, reduce tumor volume, and increase survival in an MC-38-OVA murine model of colon cancer.

References:
[1]. Qi, S., Zhang, X., Yu, X., et al.Supramolecular lipid nanoparticles based on host-guest recognition: A new generation delivery system of mrna vaccines for cancer immunotherapyAdv. Mater.36(23)e2311574(2024).

Product Documents

Purity:>95.00%Appearance:A solution in methyl acetate
COASDSData Sheet

Chemical Properties

CAS No.
2924606-55-1
Chemical Name
9Z-octadecenoic acid, 3-[2-[(2-hexyl-1-oxodecyl)oxy]ethyl]-14-hydroxy-12-(2-hydroxyethyl)-7-oxo-6-oxa-3,8,12-triazatetradec-1-yl ester
SMILES
O=C(CCCCCCC/C=C\CCCCCCCC)OCCN(CCOC(NCCCN(CCO)CCO)=O)CCOC(C(CCCCCCCC)CCCCCC)=O
Molecular Formula
C48H93N3O8
Molecular Weight
840.3
Solubility
DMSO: Soluble: ≥10 mg/ml,Ethanol: Soluble: ≥10 mg/ml
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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